ID W5Q0L2_SHEEP Unreviewed; 468 AA.
AC W5Q0L2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Serpin domain-containing protein {ECO:0000259|SMART:SM00093};
GN Name=SERPINA5 {ECO:0000313|Ensembl:ENSOARP00000016248.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016248.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000016248.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016248.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000016248.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR EMBL; AMGL01042990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q0L2; -.
DR SMR; W5Q0L2; -.
DR STRING; 9940.ENSOARP00000016248; -.
DR PaxDb; 9940-ENSOARP00000016248; -.
DR Ensembl; ENSOART00000016482.1; ENSOARP00000016248.1; ENSOARG00000015144.1.
DR eggNOG; KOG2392; Eukaryota.
DR HOGENOM; CLU_023330_2_1_1; -.
DR OMA; QVPMMNR; -.
DR Proteomes; UP000002356; Chromosome 18.
DR Bgee; ENSOARG00000015144; Expressed in liver and 35 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd19553; serpinA5_PCI; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF274; PLASMA SERINE PROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..468
FT /note="Serpin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004871333"
FT DOMAIN 110..468
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 468 AA; 52335 MW; 5370E94767813378 CRC64;
MIAPSSLWPW VGGLVLRLRT TFSSHTAGDP DLLAPVQPVL YQALRTVASA VCTLIIRQKR
GLATMRLCLF LCLVLLGPRM ATLRRPQKKK IQEVPPAATT ASPGSRDFVF DLYRTLAAAA
PDQNIFFSPL SISLSLAMLS LGARSNTKVQ ILEGLGIGPG EGSEEELHGA SQRLLRELQQ
PRDSLQLSLG NALFTKPTLP IQEAFLGAMR TLYLADTFPT DFENPEGAKK NINDYVEKQT
KGKIVDLIKS LDGTQVMVMV NYIFFKAKWE TSFNLKSTHE QDFYVTPETV VRVPMMKQQD
QFYYLLDRNL SCKVVGVPYQ GNATAFFILP REGDMEQVEN GLKEKTLKKW LRMPMKRRLE
LYLPKFSIEG SYQLEEVLPK LGIRDVFTSN ADLTGISNHS SIWLSEMVHK AVVEVDESGT
QAAAATGTVI TFKSARLGSQ RIVFNRPFLM LIVENSKHIL FFGKVTRP
//
