ID W5Q1T1_SHEEP Unreviewed; 684 AA.
AC W5Q1T1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=SH3RF1 {ECO:0000313|Ensembl:ENSOARP00000016669.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016669.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000016669.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016669.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000016669.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; AMGL01051580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01051581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01051582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01051583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q1T1; -.
DR SMR; W5Q1T1; -.
DR STRING; 9940.ENSOARP00000016669; -.
DR PaxDb; 9940-ENSOARP00000016669; -.
DR Ensembl; ENSOART00000016907.1; ENSOARP00000016669.1; ENSOARG00000015541.1.
DR eggNOG; KOG2177; Eukaryota.
DR HOGENOM; CLU_015769_1_0_1; -.
DR OMA; NMIIAPS; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000015541; Expressed in rectum and 53 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd11930; SH3_SH3RF1_2; 1.
DR CDD; cd11785; SH3_SH3RF_C; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035816; SH3RF1/SH3RF3_SH3_4.
DR InterPro; IPR035795; SH3RF1_SH3_2.
DR PANTHER; PTHR14167:SF62; E3 UBIQUITIN-PROTEIN LIGASE SH3RF3; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 2.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50002; SH3; 4.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..64
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 67..130
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 310..371
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 625..684
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 141..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 71597 MW; 07B04FF65644879A CRC64;
LQGIPQLPCA KALYNYEGKE PGDLKFSKGD IIVLRRQVDE NWYHGEVGGV HGFFPTNFVQ
IIKPLPQPPP QCKALYDFEV KDKEADKDCL PFAKDDVLTV IRRVDENWAE GMLADKIGIF
PISYVEFNSA AKQLIEWDQP PGPAVAAGEG ALATTPSSTA PKQPDGKKNT KKRHSFTSLS
MASKASQAAQ QRHSMEISPP VLISSSNPAA AARIGELAGL SCSAPSQVHI STTGLIVTPP
PSSPVTTGPS FTFPAEAPYP AALATLNPPL PPPPLQAATP TGTAVAAAAG LGPRPTAGPT
DQTTHPRPQP RPSVYVAIYP YTPRKEDELE LRKGEMFLVF ERCQDGWFKG TSMHTSKIGV
FPGNYVAPVT SRAVTSASQG KVPMLTTGPA SRGGVPANPP PAGGPAQKPP GNGVAGGPGV
PTAVVSAAHV QTSPQAKVLL HVSGQMTVNQ ARSAARTVSA HSQERPTAAV TPIQVQSTQA
QSHYPPDTPQ PPHPPAHAAA SGLGRVGGPL ACTTAPASIP AASLEPEPSG RPLTLLPGTP
TSPDSGSAAR PDKDGKKEKK GLLKLLSGAS TKRKPRGSPP ASPTLDAELC ACMSSSCSLD
SAPVAPPPRQ PCSSLGPTAS EVRPAVCERH RVVVSYPPQS EAELELKEGD IVFVHKKRED
GWFKGTLQRN GKTGLFPGSF VENI
//
