ID W5Q1V1_SHEEP Unreviewed; 2476 AA.
AC W5Q1V1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Centrosomal protein of 290kDa coiled-coil region domain-containing protein {ECO:0000259|Pfam:PF16574};
GN Name=CEP290 {ECO:0000313|Ensembl:ENSOARP00000016689.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016689.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000016689.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016689.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000016689.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120}.
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DR EMBL; AMGL01079901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01079902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01079903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01079904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01079905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOART00000016927.1; ENSOARP00000016689.1; ENSOARG00000015531.1.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000015531; Expressed in testis and 54 other cell types or tissues.
DR ExpressionAtlas; W5Q1V1; baseline.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR InterPro; IPR032321; Cep209_CC5.
DR InterPro; IPR026201; Cep290.
DR PANTHER; PTHR18879; CENTROSOMAL PROTEIN OF 290 KDA; 1.
DR PANTHER; PTHR18879:SF20; CENTROSOMAL PROTEIN OF 290 KDA; 1.
DR Pfam; PF16574; CEP209_CC5; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 1283..1410
FT /note="Centrosomal protein of 290kDa coiled-coil region"
FT /evidence="ECO:0000259|Pfam:PF16574"
FT REGION 2031..2052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 59..291
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 317..370
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 400..434
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 459..559
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 610..658
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 692..726
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 778..872
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 956..1021
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1074..1101
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1215..1242
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1284..1318
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1345..1393
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1461..1488
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1529..1588
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1642..1892
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1971..2029
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2066..2237
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2273..2448
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2476 AA; 290682 MW; 3B084CA0D976AFAA CRC64;
MPPNINWKEI RKVDPDELPR QEELADNLLI SLSKVEVNEL KSESQENMIH LFRITQSLMK
MKAQEVELAL EEVEKAGEEQ AKFENQLKTK VMKLENELEM AQHSAGGRDT RFLRDEIRQL
EKQLEQKDRE LEDMEKELEK EKKVNEQLAL RNEEAENENS KLRRENEQLR QDIIDYQKQI
DSQKETLLSR RGEDSDYRSQ LSKKNYELVQ YLDEIQTLTE ANEKIELQNQ EMRKNLEESV
QEMEKMTDEY NRMKAVVHQT DSMMDQLKKE NDHYRLQVQE LTDLLKTKNE EDDPIMAAVN
AKVEEWKLIL SSKDDEIIEY QQMLHSLRDK LKNAQLDADK SNVMALQQGI QERDSQIKML
SEQVEQYTKE MEKNTFIIED MKNELQRNKG ASTLSQRTHY MKIQSKVQIL EERTKEAERT
AELAEADARE KDKELVETLK RLKDYESGVY GLEDAVIEIK NCKNQIKIRD REIEVLTKEI
NKLELKINDF LDENEALRER MGLEPTTMID LTEFRNSKSL KQQQYRAENQ ILLKEIESLE
EERLDLKKKI RQMAQEKGKR TVTSGLIAED LNLTEHFSQE NRMGERKSDF MSLKNMSEGQ
SKNEFLSREL IEKERDLERS RTVIAKFQNK LKELVEENKQ LEEGMKEILQ AIKEMQKDPD
IKGECSSYFI PLLIFYFKAI ESKNAEGIFD ANLHLKAQVD QLTGRNEELR QELRESRKEA
INYSQQLTKA HLKIDYLEKE TSLLRQTEGS NIVFKGIDLP DGIAPSSANI INSQNEYLIH
ILQELEYKEN KLKNLEDSLE DYNRKFAVIR HQQSLLYKEY LSEKENWKTE SETMKEEKKR
LEDQIQQDAI KVKEYNNLLS ALQMDSDEMK KTLAENSRKI TVLQVNEKSL IRQYTTLVEM
ERQLRKENGK QKNELMSMEA EVGEKIGRLQ RFKEMAIFKI AALQKVVDNS VSLSELELAN
RQYNELTAKY RDILQKDNML VQRTNNLEHL ECENVSLKEQ MESISKELEI TKEKLHTIEQ
AWEQETKLGN ESNMDKAKKS VTNSEIVSIS KKITMLEMKE LNERQRAEHS QKMYEHVKTS
LQQMEERNFE LETKFAELTR INLEAQKVEQ MLRDELADSV SKTVSDADRQ HILELEKSEM
ELKVEVSKLK EISDIAKRQV EILNAQQQSR EREAESIRTQ LLDYQAQSDE KALIAKLHQH
IVSLQASEAT ALGKLESVTS KLQKMEAHNL RLEQKLDEKE QALFYARLEG RNRAKHLRQT
IQSLRRQFSG ALPLAQQEKF SKTMIQLQND KLRIMEEMKN SQQEHRSLKN KTLEMELKLK
GLEDLISTLK DARGAQKVIS WHTKIEELRL QELKLNRELV KDKEEIKYLN NIISEYENTI
RSLEEEIVQQ NKFHEERQMA WDQREVELER QLDVFDRQQN EILSEAQKFE EATGSMPDPS
LPIPNQLEIA LRKIKENIRI ILETQATCRS LEEKLREKES ALRLAEENIL SRDKVINELR
LRLPATAEQE KLIAEFSRKE VEPKSHHTLK LAHQTIANMQ ARLNQKEEVL KKYQHLLEKA
REEQREIVKK HEEELHILHR KLELQADNSL SKFKETAWDL IKQSPTPVPT NKHFIRLAEM
EQTVAEQDDS LSSLVIKLKQ VSQDLERQKE ITELKIKEFE NMKLRLQENH ADEVKKIKAE
VENLRCLLVQ SQKESQSLKS ELQTQKEANS RAPTTTMRNL VERLKSQLAL KEKQQKALSR
ALLELRAEMT AAAEERIISV TSQKEANLNV QQIVDRHTKE LKSQIEDLSE NILKLKEALK
TSKNRENSLT DNLNDLTNEL QNKQKAYGKV LREKDGVDQE NNELKRQIKR LTSGLQGKPL
IDNKQSLIEE LQKKIKKLES QLERKVDEAE MKPMKEKSAR EEVIRWEEGK KWQTKIEGIR
NKLKEKEGEV YILTKQLTTL KDLFAKADKE KLTLQRKLKT TGLTVDQVMA VRVLESEKEL
EELKKRNLDL ENDISYMRTH QALPRDSVIE DLRLQNKYLQ EKLHALEKQF SKDAYSRPST
SGIDSDDHYQ REQELQRENL KLSSENIELK FQLEQANKDL PRLKNQVRDL KEMCEFLKKE
KAEVERKLGH VRGSGRSGKT IPELEKTIGL MKKVVEKVQR ENEQLKKASG ILTSEKMANI
EMENEKLKAE LEKLKVHLGR QLSMHYESKA KGTEKIVAEN DRLRKELKKE TEAAEKLRIA
KNNLEILNEK MTVQLEESGK RLQLAESRGP QLEGADSKSW KSIVVTRMYE TKLKELETDI
AKKTKSLTDL KQLVRQATER EQRVKKYTAD LEQQIEILKH VPEGDETEQG LQRELRVLRL
ANSQLEKEKE ELIHRIEINK DQNGPESTIS VGADPDQLKE KVKDLETQLR TSDMEKQHLK
EEIKKLKKEL ENFDPSFFEE IEDLKYNYKE EVKKNILLEE KLKKLSEQFG VELTSPVAAS
EQFEDEEENP VNFPIY
//
