ID W5Q1X4_SHEEP Unreviewed; 857 AA.
AC W5Q1X4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=CUB domain-containing protein {ECO:0000259|PROSITE:PS01180};
GN Name=LRP12 {ECO:0000313|Ensembl:ENSOARP00000016712.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016712.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000016712.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016712.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000016712.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00037878}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; AMGL01112406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01112410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q1X4; -.
DR SMR; W5Q1X4; -.
DR STRING; 9940.ENSOARP00000016712; -.
DR PaxDb; 9940-ENSOARP00000016712; -.
DR Ensembl; ENSOART00000016950.1; ENSOARP00000016712.1; ENSOARG00000015579.1.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_013747_0_0_1; -.
DR OMA; YTCIPES; -.
DR Proteomes; UP000002356; Chromosome 9.
DR Bgee; ENSOARG00000015579; Expressed in cerebellum and 52 other cell types or tissues.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF47; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 12; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 5.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 44..156
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 256..369
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 621..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 163..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 170..188
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 182..197
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 236..251
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 392..407
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 430..445
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 448..460
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 455..473
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 467..482
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 857 AA; 94297 MW; C046A53C41E9BD9E CRC64;
MSSALAGGFF TTEPPGRSLI NNKGNGALAE HSENVHISGV STACGETPEQ IRAPSGIITS
PGWPSEYPAR INCSWFIRAN PGEIITISFQ DFDIQGSRRC SLDWLTIETY KNIESYRACG
STIPPPYISS QDHVWIRFHS DDSISRKGFR LAYFSGKSEE PNCACDQFRC GNGKCIPAAW
KCNNMDECGD SSDEEICARE ANPPTSASFQ PCAYNQFQCL SRFTKVYTCL PESLKCDGNI
DCLDLGDEID CDVPTCGQWL KYFYGTFNSP NYPDFYPPGS NCTWLIDTGD HRKVILRFTD
FKLDGTGYGD YVKIYDGLEE NPHKLLRVLT AFDSHAPLTV VSSSGQIRVH FCADKVNAAR
GFNATYQVDG FCLPWEIPCG GNWGCYTEQQ RCDGYWHCPN GRDEINCTVC QKEEFPCSRN
GVCYPRSDRC NYQNHCPNGS DEKNCFFCQP GNFHCKNNRC VFESWVCDSQ DDCGDGSDEE
NCPVIVPTRV ITAAVIGSLI CGLLLVIALG CTCKLYSLRM FERRSFETQL SRVEAELLRR
EAPPSYGQLI AQGLIPPVED FPVCSPNQQA SVLENLRLAV RSQLGFTSIR LPMAGRSSNI
WNRIFNFARS RHSGSLALVS ADGDEVVPSQ STSREPERNH THRSLFSVES DDTDTENERR
DTAGASGGVA APLPQKVPPT TAVEATVGAS GSSSTQSTRG GHTETGRDVT GVEPPSVSPA
RHQLTSALSR MTQGLRWVRF TLGRSSSVNQ NQSPLRQLDN GVNGREEDDD VEMLIPVSEG
ASDFDVSDCS RPLLDLPSDQ GQGFRQPYSG TNPGVRPSSR DGPCERCGIV HTAQIPDSCL
EATLKTETSD DEALLLC
//
