ID W5Q2H2_SHEEP Unreviewed; 889 AA.
AC W5Q2H2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Solute carrier family 12 member 9 {ECO:0000256|ARBA:ARBA00019359};
GN Name=SLC12A9 {ECO:0000313|Ensembl:ENSOARP00000016910.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016910.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000016910.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016910.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000016910.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; AMGL01069432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004021053.1; XM_004021004.3.
DR AlphaFoldDB; W5Q2H2; -.
DR SMR; W5Q2H2; -.
DR STRING; 9940.ENSOARP00000016910; -.
DR PaxDb; 9940-ENSOARP00000016910; -.
DR Ensembl; ENSOART00000017149.1; ENSOARP00000016910.1; ENSOARG00000015749.1.
DR eggNOG; KOG1288; Eukaryota.
DR HOGENOM; CLU_001883_3_0_1; -.
DR OMA; VANVFSC; -.
DR Proteomes; UP000002356; Chromosome 24.
DR Bgee; ENSOARG00000015749; Expressed in ileocolic lymph node and 50 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF98; SOLUTE CARRIER FAMILY 12 MEMBER 9; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..535
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 547..634
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 646..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 93240 MW; 4D2F7BC97A1460C2 CRC64;
MASENSPLLA YRLLGEEGVS FPANGAGGPG GAPARKLSTF LGVVVPTVLS MFSIVVFLRI
GFVVGHAGLL QALAMLLVAY VILALTVLSV CAIATNGAVR GGGAYFMISR TLGPEVGGSI
GLMFYLANVC GCAVSLLGLV EAILDVFGAD ASGSSGLRVL PQGYGWSLLY GSLLLGLVGG
VCTLGAGLYA RASFLTFLLV SGSLASVLVS FVAVGPRDIP LAPRPGPNGS SLPPQVGHFT
GFNSSTLKAN LDAGYAKDYT TGAMMTFASV FAVLFNGCTG IMAGANMSGE LKDPSRAIPL
GTIVAVAYTF FIYILLFFLS SFTCDRVLLQ EDYGFFRAIS LWPPLVLVGI YATSLSASMS
SLIGASRILH ALAQDDLFGV VLAPAKVVSR GGNPWGAVLY SWGLVQLVLL AGKLNTLAAV
VTVFYLVAYA AVDLSCLSLE WASAPNFRPT FNLFSWHTCL LGVASCLLMM FLISPGAAGG
SLLLMGLLSA LPGAGGGPSS WGYVSQALLF HQVRKYLLRL DVRKDHVKFW RPQLLLLVGN
PRGALPLLRL ANQLKKGGLY VLGHVTLGDL DSLPSDPVQP QYGAWLSLVD RAQVKAFVDL
TLSPSVRQGA QHLLRISGLG GMKPNTLVLG FYDDAAPQDH FLTDPAFSEP ADGTQEAGAP
ALSTLFPPPR APGSPRALSP QDYVATVADA LKMNKNVVLA RACGALPPER LSRGSGGTSQ
LHHVDVWPLN LLRPRGGPGY VDVCGLFLLQ MATILGMVPA WHSARLRIFL CLGPREAPGA
AEGRLRALLS QLRIRAEVRE VVWGEGAASE EPEEEEEGDF VNGRRGDAEA EALACSANAL
VRAQQGPGWG GIGGAGEGLR YLALLEILSR DLGPALLIHG VTPVTCTDL
//
