ID W5Q2L5_SHEEP Unreviewed; 209 AA.
AC W5Q2L5; A0A6P7E5X7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Nucleoside diphosphate kinase-like domain-containing protein {ECO:0000259|SMART:SM00562};
GN Name=NME5 {ECO:0000313|Ensembl:ENSOARP00000016953.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016953.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000016953.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016953.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000016953.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NDK family. {ECO:0000256|ARBA:ARBA00008142,
CC ECO:0000256|RuleBase:RU004011}.
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DR EMBL; AMGL01093010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01093011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01093012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004008873.1; XM_004008824.3.
DR AlphaFoldDB; W5Q2L5; -.
DR SMR; W5Q2L5; -.
DR STRING; 9940.ENSOARP00000016953; -.
DR PaxDb; 9940-ENSOARP00000016953; -.
DR Ensembl; ENSOART00000017194.1; ENSOARP00000016953.1; ENSOARG00000015794.1.
DR eggNOG; KOG0888; Eukaryota.
DR HOGENOM; CLU_060216_2_0_1; -.
DR OMA; HNAISYW; -.
DR OrthoDB; 5471350at2759; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000015794; Expressed in fallopian tube and 46 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0001534; C:radial spoke; IEA:Ensembl.
DR GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
DR GO; GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR GO; GO:0006228; P:UTP biosynthetic process; IEA:InterPro.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR CDD; cd22970; DD_NDKH5-like; 1.
DR CDD; cd04418; NDPk5; 1.
DR Gene3D; 1.20.890.10; cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain; 1.
DR Gene3D; 3.30.70.141; Nucleoside diphosphate kinase-like domain; 1.
DR InterPro; IPR007858; Dpy-30_motif.
DR InterPro; IPR034907; NDK-like_dom.
DR InterPro; IPR036850; NDK-like_dom_sf.
DR InterPro; IPR012410; NDK_H5.
DR InterPro; IPR001564; Nucleoside_diP_kinase.
DR PANTHER; PTHR46161; NUCLEOSIDE DIPHOSPHATE KINASE; 1.
DR PANTHER; PTHR46161:SF1; NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5; 1.
DR Pfam; PF05186; Dpy-30; 1.
DR Pfam; PF00334; NDK; 1.
DR PIRSF; PIRSF036504; NDK_H5; 1.
DR PRINTS; PR01243; NUCDPKINASE.
DR SMART; SM00562; NDK; 1.
DR SUPFAM; SSF54919; Nucleoside diphosphate kinase, NDK; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 12..150
FT /note="Nucleoside diphosphate kinase-like"
FT /evidence="ECO:0000259|SMART:SM00562"
SQ SEQUENCE 209 AA; 23752 MW; 51151431B77184D7 CRC64;
MELSMPPPQI YVEKTLAIIK PDIVDKEEEI QDIILRSGFT IVQRRKLHLS PEHCSNFYVE
QYGKMFFPNL TAYMSSGPLV AMILARYNAI SYWKELLGPS NSLVAKETHP DSLRAIYGTD
ELRNALHGSN DFAAAEREIR FMFPAVIVEP IPVGQAAKDY LNLYVTPTLL KGLTELCKQK
PADPFIWLAD WLLKNNPNKP KLCHHPVAE
//
