ID W5Q3B4_SHEEP Unreviewed; 1199 AA.
AC W5Q3B4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Tubulin-specific chaperone D {ECO:0000256|ARBA:ARBA00015003};
GN Name=TBCD {ECO:0000313|Ensembl:ENSOARP00000017202.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000017202.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000017202.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000017202.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000017202.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TBCD family.
CC {ECO:0000256|ARBA:ARBA00006853}.
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DR EMBL; AMGL01018993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01018994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01018995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01018996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q3B4; -.
DR STRING; 9940.ENSOARP00000017202; -.
DR PaxDb; 9940-ENSOARP00000017202; -.
DR Ensembl; ENSOART00000017443.1; ENSOARP00000017202.1; ENSOARG00000016006.1.
DR eggNOG; KOG1943; Eukaryota.
DR HOGENOM; CLU_003043_0_0_1; -.
DR OMA; EPHEAWH; -.
DR Proteomes; UP000002356; Chromosome 11.
DR Bgee; ENSOARG00000016006; Expressed in leukocyte and 52 other cell types or tissues.
DR GO; GO:0048487; F:beta-tubulin binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR GO; GO:0007021; P:tubulin complex assembly; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR033162; TBCD.
DR InterPro; IPR022577; Tubulin_specific_chaperoneD_C.
DR PANTHER; PTHR12658; BETA-TUBULIN COFACTOR D; 1.
DR PANTHER; PTHR12658:SF0; TUBULIN-SPECIFIC CHAPERONE D; 1.
DR Pfam; PF12612; TFCD_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 909..1095
FT /note="Tubulin-specific chaperone D C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12612"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1199 AA; 132963 MW; 8163500DA164ECA4 CRC64;
MALSEEPAAG AAEDPAEDPV EDAAEDAALA CGAALESFGE SAETRELLGR LPAVLADRSA
REGALERFRV IMDKYQEQPH LLDPHLEWML NLLLEFVQNK ASPADLVHLA FKFLYIISKV
RGYKTFLRLF PHEVADVHPV LDMFTNQNPK DHETWETRYM LLLWLSVTCL IPFDFSRLDG
NLLSQPGQER VSTMDRILQV AESYLVVSDK ARDAAAVLVS KFVTRPDVKQ KKMASFLDWS
LCTLARSSFQ TIEGVIAMDG TLQALAQIFK HGKREDCLPY AATVLQCLDS CRLPDSNQTL
LRKLGVKLVQ RLGLTFLKPR VAGWRYQRGC RSLAESLQHS IQNPKEPMTQ AETPDSDGED
DVPAEVESVI EQLLVGLKDK DTIVRWSAAK GIGRMAGRLP KELADDVTGS VLDCFSFQET
DSAWHGGCLA LAELGRRGLL LPSRLSDVVP VILKALTYEE KRGACSVGSN VRDAACYVCW
AFARAYEPQE LKPFVAAISS ALVIATVFDR DVNCRRAASA AFQENVGRQG TFPHGIDILT
TADYFAVGNR SNCFLVISMF IAGFPEYTQP MIEHLVTMKI NHWDGTIREL SAKALRNLAQ
RAPEHTACEV FPRLLSKTQS PDLHTRHGAV LACAEVARSL HTLATQQGRP VSDFLDEKAM
RGLKQIHQQL YDRQLYRGLG GELMRQAVCI LIENLALSKM PFRGDAVIDG WQWLINDTLR
NLHLISSHSR QHIKEAAVSA LAALCSEYHA REPGEAEAAA QEELVRLYLA ELQSPEEMTR
CGCALALGAL PAFFLKGRLQ QVLAGLRAVT HISSKDVSFA EARRDALKAI SRICQTVGVR
AEGPPDEALC RENVSQIYCT LLDCLKDYTT DSRGDVGAWV REAAMTSLMD LTLLLGRNQP
ELIEAPLCQR LMCCLAQQAS EKIDRFRAHA ARVFLALLHA DSPAIPHVPA RPELERLFPR
YWAPLRGGGS PAPPRCMARL LGLPAYRYHV LLGLAVSVGG LTESTVRYST QGLFEHMKEI
QNDPAALEDF GGTLLQVFED NLLNDRVSVP LLKTLDQMLA NGCFDVFTTQ EDHPFCVKLL
ALCKEEIKKS KDVQKLRSSI AVFCGLVQFP GDVRKKALLQ LFLLLCHPFP VIRKHTASQV
YEMVLTYDVV PAAVLDEVMA VLSSTAWDAE LPVVRAQRNH LCDLLGVPRP QLVPKVSLA
//
