ID W5Q3I5_SHEEP Unreviewed; 400 AA.
AC W5Q3I5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=GDNF/GAS1 domain-containing protein {ECO:0000259|SMART:SM00907};
GN Name=GFRA3 {ECO:0000313|Ensembl:ENSOARP00000017274.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000017274.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000017274.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000017274.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000017274.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961}.
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DR EMBL; AMGL01093016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01093017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q3I5; -.
DR SMR; W5Q3I5; -.
DR STRING; 9940.ENSOARP00000017274; -.
DR PaxDb; 9940-ENSOARP00000017274; -.
DR Ensembl; ENSOART00000017519.1; ENSOARP00000017274.1; ENSOARG00000016086.1.
DR eggNOG; ENOG502QWSW; Eukaryota.
DR OMA; NSISWMG; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000016086; Expressed in vas deferens and 45 other cell types or tissues.
DR ExpressionAtlas; W5Q3I5; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR InterPro; IPR003505; GDNF_rcpt_A3.
DR PANTHER; PTHR10269:SF15; GDNF FAMILY RECEPTOR ALPHA-3; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 3.
DR PRINTS; PR01319; GDNFRALPHA3.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; GDNF receptor-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..400
FT /note="GDNF/GAS1 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004870153"
FT DOMAIN 38..119
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 156..233
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 242..334
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
SQ SEQUENCE 400 AA; 44459 MW; 7A2D39DEAADD8F87 CRC64;
MARPRNPRPL PPALLLLLPL LLRAGDHLPT EGRLTNSCIQ ARRKCQADPT CNATYHYLNS
CASSISTSSP AEEPLVPEDC MEAAQQLRNS SLMSCTCHRR MKNQATCLNI YWTIHPARSL
GDYELDVSPY EDTVTRKPWK MNLSKLNMLI PDSDLCLKFA MLCTLNDKCD RLRKAYGEAC
SGSRCQRHTC QRQLRAFFEK ASEPHSQGLL LCPCAPTDQG CGQRRRNTIA PSCALPPEAP
NCLELRHVCV SDPLCRSRLA DFQTHCHPMD ILGTCATEES RCLRAYMGLI GTALTPNFVS
NINASVALSC TCRGSGNLQE ECERLEESFS HNPCLMEAIS AKMRFHSQLF SQDWAASTFS
VMERQVGAPL LYPLLPFLDH QGKPRQGGQE TGGGVSSFWS
//
