ID W5Q437_SHEEP Unreviewed; 386 AA.
AC W5Q437;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|RuleBase:RU369070};
DE Short=HIB-CoA hydrolase {ECO:0000256|RuleBase:RU369070};
DE Short=HIBYL-CoA-H {ECO:0000256|RuleBase:RU369070};
DE EC=3.1.2.4 {ECO:0000256|RuleBase:RU369070};
DE AltName: Full=3-hydroxyisobutyryl-coenzyme A hydrolase {ECO:0000256|RuleBase:RU369070};
GN Name=HIBCH {ECO:0000313|Ensembl:ENSOARP00000017476.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000017476.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000017476.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000017476.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000017476.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline
CC catabolite. Has high activity toward isobutyryl-CoA. Could be an
CC isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also
CC hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000256|ARBA:ARBA00024871}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709,
CC ECO:0000256|RuleBase:RU369070};
CC -!- PATHWAY: Amino-acid degradation; L-valine degradation.
CC {ECO:0000256|ARBA:ARBA00005109, ECO:0000256|RuleBase:RU369070}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|RuleBase:RU369070}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254, ECO:0000256|RuleBase:RU369070}.
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DR EMBL; AMGL01051937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01051938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01051939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004004547.1; XM_004004498.3.
DR AlphaFoldDB; W5Q437; -.
DR SMR; W5Q437; -.
DR STRING; 9940.ENSOARP00000017476; -.
DR PaxDb; 9940-ENSOARP00000017476; -.
DR Ensembl; ENSOART00000017723.1; ENSOARP00000017476.1; ENSOARG00000016273.1.
DR GeneID; 101111161; -.
DR KEGG; oas:101111161; -.
DR CTD; 26275; -.
DR eggNOG; KOG1684; Eukaryota.
DR HOGENOM; CLU_009834_22_1_1; -.
DR OMA; EWEKSDM; -.
DR OrthoDB; 3639304at2759; -.
DR UniPathway; UPA00362; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000016273; Expressed in heart right ventricle and 54 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 3: Inferred from homology;
KW Branched-chain amino acid catabolism {ECO:0000256|ARBA:ARBA00022456};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU369070};
KW Mitochondrion {ECO:0000256|RuleBase:RU369070};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 47..376
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 386 AA; 43386 MW; 1E359FD900311CDE CRC64;
MGLQELCRLM SRFNSYKRTN IILQHLKMSN HTDAAAEVLL ERKGCAGVIT LNRPRFLNTL
TLGMIRQIYP QLKKWEQDPE TFLIIIKGAG EKAFCAGGDI RALSEARNTN QKMLQDLFRE
EYILNNAIDS CQKPYIALIH GITMGGGVGV SVHGQFRVAT EKSVFAMPET AIGLFPDVGG
GYFLPRLQGK LGYFLALTGF RLKGRDVYTA GIATHFVDFE KLGMLEEDLL ALKSPSKENI
ADVLEAYHAK SKIDQDKPFI LEEHMDKINS WFSANTVEQI VDNLQQDGSS FALEQLKVIN
KMSPTSLKIT LRQLLEGSSK TLPEVLTMEY RLSQACMKGH DFHEGVRAVL IDKDQSPKWK
PADLKEVTDE DLNDYFKSLG SNDLKF
//
