GenomeNet

Database: UniProt
Entry: W5Q503_SHEEP
LinkDB: W5Q503_SHEEP
Original site: W5Q503_SHEEP 
ID   W5Q503_SHEEP            Unreviewed;       635 AA.
AC   W5Q503; A0A6P3E8G9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=E3 ubiquitin-protein ligase ZSWIM2 {ECO:0008006|Google:ProtNLM};
GN   Name=ZSWIM2 {ECO:0000313|Ensembl:ENSOARP00000017793.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000017793.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000017793.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000017793.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000017793.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AMGL01052085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004004567.1; XM_004004518.3.
DR   AlphaFoldDB; W5Q503; -.
DR   SMR; W5Q503; -.
DR   STRING; 9940.ENSOARP00000017793; -.
DR   PaxDb; 9940-ENSOARP00000017793; -.
DR   Ensembl; ENSOART00000018044.1; ENSOARP00000017793.1; ENSOARG00000016567.1.
DR   GeneID; 101115760; -.
DR   KEGG; oas:101115760; -.
DR   CTD; 151112; -.
DR   eggNOG; KOG0800; Eukaryota.
DR   HOGENOM; CLU_029121_0_0_1; -.
DR   OMA; RNQKWRS; -.
DR   OrthoDB; 140984at2759; -.
DR   Proteomes; UP000002356; Chromosome 2.
DR   Bgee; ENSOARG00000016567; Expressed in testis and 5 other cell types or tissues.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR   CDD; cd16486; mRING-H2-C3H2C2D_ZSWM2; 1.
DR   CDD; cd16494; RING-CH-C4HC3_ZSWM2; 1.
DR   Gene3D; 3.30.60.90; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR007527; Znf_SWIM.
DR   InterPro; IPR000433; Znf_ZZ.
DR   InterPro; IPR043145; Znf_ZZ_sf.
DR   InterPro; IPR039903; Zswim2.
DR   PANTHER; PTHR21540:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2; 1.
DR   PANTHER; PTHR21540; RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF04434; SWIM; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 2.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS50089; ZF_RING_2; 2.
DR   PROSITE; PS50966; ZF_SWIM; 1.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT   DOMAIN          54..87
FT                   /note="SWIM-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50966"
FT   DOMAIN          147..199
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          230..281
FT                   /note="ZZ-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50135"
FT   DOMAIN          345..386
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
SQ   SEQUENCE   635 AA;  73260 MW;  C07300D7D44FBB6D CRC64;
     MLRGGCKASE RRKHLIDRLS WQQDQALSST IYLLREMGPT AFLLREEEPE NRDFRVSLGN
     PHVCNCSTFL KGGELCKHIC WVLLKKFRLP RNHESALQLG LVEREINDLL QGIHRVQTPQ
     REMNDENPQI EEDGYIKQKE ISSDDICSIC QEVLLEKMLP VTFCRFGCGN SVHIKCMKIL
     ANYQDVTLNS SMLKCPLCRK DFGPLNLILE EFKNSNKLVT ASEKERLDKH LGIPCNNCQQ
     FPLEGKCYKC TTCIEYHLCQ DCFDSCCHLS HSFMFREKRN QKWRSLEKRS DKTVKYVDIK
     NEIEEKMPHF QEKQDHIYTP KHVVKSLPLF LITKKSKLLA PGYQCRLCLK AFRRGQHARL
     LPCTHKFHRK CIDSWLLHKC NSCPIDGQVI YNPLIWKDRA VNGHVHHSVS NTDITHLPKR
     EEPELFIPGT GLVLKQNKPG ILPILPQRNS EKLNTPQSPN DAYQNITIDN LYSIKLDDSN
     SRKSIYECKI NQHFSSYLQD LPTGSFGKTS SQTLFPSIDH KNIIHPTEMK NPCINKKHHT
     SQSQKMNKSC KGTNHNSKKI LGNKVREDNT RSNTLLPDLN LIVNWGTTKL SLSNRYNNCM
     GKIRPKCSHL SRRPISHPLN TKSPELSLIL KGVHL
//
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