ID W5Q503_SHEEP Unreviewed; 635 AA.
AC W5Q503; A0A6P3E8G9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=E3 ubiquitin-protein ligase ZSWIM2 {ECO:0008006|Google:ProtNLM};
GN Name=ZSWIM2 {ECO:0000313|Ensembl:ENSOARP00000017793.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000017793.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000017793.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000017793.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000017793.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01052085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004004567.1; XM_004004518.3.
DR AlphaFoldDB; W5Q503; -.
DR SMR; W5Q503; -.
DR STRING; 9940.ENSOARP00000017793; -.
DR PaxDb; 9940-ENSOARP00000017793; -.
DR Ensembl; ENSOART00000018044.1; ENSOARP00000017793.1; ENSOARG00000016567.1.
DR GeneID; 101115760; -.
DR KEGG; oas:101115760; -.
DR CTD; 151112; -.
DR eggNOG; KOG0800; Eukaryota.
DR HOGENOM; CLU_029121_0_0_1; -.
DR OMA; RNQKWRS; -.
DR OrthoDB; 140984at2759; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000016567; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR CDD; cd16486; mRING-H2-C3H2C2D_ZSWM2; 1.
DR CDD; cd16494; RING-CH-C4HC3_ZSWM2; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR007527; Znf_SWIM.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR InterPro; IPR039903; Zswim2.
DR PANTHER; PTHR21540:SF0; E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2; 1.
DR PANTHER; PTHR21540; RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF04434; SWIM; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS50089; ZF_RING_2; 2.
DR PROSITE; PS50966; ZF_SWIM; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 54..87
FT /note="SWIM-type"
FT /evidence="ECO:0000259|PROSITE:PS50966"
FT DOMAIN 147..199
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 230..281
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 345..386
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 635 AA; 73260 MW; C07300D7D44FBB6D CRC64;
MLRGGCKASE RRKHLIDRLS WQQDQALSST IYLLREMGPT AFLLREEEPE NRDFRVSLGN
PHVCNCSTFL KGGELCKHIC WVLLKKFRLP RNHESALQLG LVEREINDLL QGIHRVQTPQ
REMNDENPQI EEDGYIKQKE ISSDDICSIC QEVLLEKMLP VTFCRFGCGN SVHIKCMKIL
ANYQDVTLNS SMLKCPLCRK DFGPLNLILE EFKNSNKLVT ASEKERLDKH LGIPCNNCQQ
FPLEGKCYKC TTCIEYHLCQ DCFDSCCHLS HSFMFREKRN QKWRSLEKRS DKTVKYVDIK
NEIEEKMPHF QEKQDHIYTP KHVVKSLPLF LITKKSKLLA PGYQCRLCLK AFRRGQHARL
LPCTHKFHRK CIDSWLLHKC NSCPIDGQVI YNPLIWKDRA VNGHVHHSVS NTDITHLPKR
EEPELFIPGT GLVLKQNKPG ILPILPQRNS EKLNTPQSPN DAYQNITIDN LYSIKLDDSN
SRKSIYECKI NQHFSSYLQD LPTGSFGKTS SQTLFPSIDH KNIIHPTEMK NPCINKKHHT
SQSQKMNKSC KGTNHNSKKI LGNKVREDNT RSNTLLPDLN LIVNWGTTKL SLSNRYNNCM
GKIRPKCSHL SRRPISHPLN TKSPELSLIL KGVHL
//