ID W5Q5M5_SHEEP Unreviewed; 484 AA.
AC W5Q5M5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=BTB domain-containing protein {ECO:0000259|SMART:SM00225};
GN Name=KCNS3 {ECO:0000313|Ensembl:ENSOARP00000018015.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018015.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018015.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018015.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018015.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMGL01075575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q5M5; -.
DR SMR; W5Q5M5; -.
DR STRING; 9940.ENSOARP00000018015; -.
DR PaxDb; 9940-ENSOARP00000018015; -.
DR Ensembl; ENSOART00000018267.1; ENSOARP00000018015.1; ENSOARG00000016776.1.
DR eggNOG; KOG3713; Eukaryota.
DR HOGENOM; CLU_011722_4_1_1; -.
DR OMA; FFHRPGP; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000016776; Expressed in longissimus thoracis muscle and 48 other cell types or tissues.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF39; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY S MEMBER 3; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 179..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..117
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
SQ SEQUENCE 484 AA; 54948 MW; 49414F89DC6B5F32 CRC64;
MVEAGDACIE ASVNSLVSLP SQLSTAWIHH GVWLGKLLSC HSEEAILELC DDYSVADKEY
YFDRNPSLFR YVLNFYYTGK LHVMEELCVF SFCQEIEYWG INELFLDSCC SNRYQERKEE
NHEKDWDQKS NDVSTDSSFE ESSLFEKELE KFDKLRFGQL RKKIWIRMEN PAYCLSAKLI
AISSLSVVLA SIVAMCIHSM SEFQNEDGDV DDPVLEGVEI ACIAWFTGEL AIRLVTAPCQ
KKFWKNPLNI IDFVSIVPFY ATLAVDTKEE ESEDIENMGK VVQILRLMRI FRILKLARHS
VGLRSLGATL RHSYHEVGLL LLFLSVGISI FSVLIYSVEK DDHTSSLTSI PVCWWWATIS
MTTVGYGDTH PVTLVGKLIA STCIICGILV VALPITIIFN KFSKYYQKQK DIDVDQCSED
VPEKCQELPY FNIRDIYAQR MHAFITSLSS VGIVVSDPDS TDASSIEDNE DVYNTASLEN
LPPT
//
