ID W5Q6M2_SHEEP Unreviewed; 971 AA.
AC W5Q6M2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=GPI ethanolamine phosphate transferase 2 {ECO:0000256|ARBA:ARBA00020830};
GN Name=PIGG {ECO:0000313|Ensembl:ENSOARP00000018363.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018363.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018363.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018363.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018363.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
CC {ECO:0000256|ARBA:ARBA00005315}.
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DR EMBL; AMGL01101179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01101180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01101181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012035846.1; XM_012180456.1.
DR AlphaFoldDB; W5Q6M2; -.
DR SMR; W5Q6M2; -.
DR STRING; 9940.ENSOARP00000018363; -.
DR PaxDb; 9940-ENSOARP00000018363; -.
DR Ensembl; ENSOART00000018625.1; ENSOARP00000018363.1; ENSOARG00000017110.1.
DR eggNOG; KOG2125; Eukaryota.
DR HOGENOM; CLU_004770_4_0_1; -.
DR OMA; RVKFGHD; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000002356; Chromosome 6.
DR Bgee; ENSOARG00000017110; Expressed in abdominal lymph node and 55 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR CDD; cd16024; GPI_EPT_2; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037674; PIG-G_N.
DR InterPro; IPR039527; PIGG/GPI7.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR PANTHER; PTHR23072:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2; 1.
DR PANTHER; PTHR23072; PHOSPHATIDYLINOSITOL GLYCAN-RELATED; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 420..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 749..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 909..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 944..964
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 642..954
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
SQ SEQUENCE 971 AA; 106757 MW; 282EE9EE80E6FBC4 CRC64;
MCRCDSACAG EVGRKQILRF LDAKNECKIQ FPFSFSNTLG ASSNWTELPP PLFSKVVIML
IDALRDDFVF GSKGVKFMPY TTYLVEKGSS LSFVAEAKPP TVTMPRIKAL LTGSLPGFID
VVRNLNSPTL LEDNVITRAK AAGKRIIFYG DETWVKLFPK HFVEYDGTTS FFVSDYTEVD
NNVTRHLDKV LKRQDWDVLI LHYLGLDHIG HISGPSSPLI GPKLSEMDSI LMKIHTSLLS
EERGALLPSL LALCGDHGMS EAGGHGASSM EEVNTALVLI SSAFERKPGD VRHPTHVQQT
DLAATLSVGL GLPIPKSNTG SLLFRVVEGR PVREQLRLLH LNTVQLSKLL QENVPSYKKE
PGFEQFKVAE RLHRSWVRLY LEGSNSEALA NLGAKVRRQY LDALRMLRLS LTRRAAQYDV
YSMAVGTVLV LEALALLLLG VPQALSSRAE LDVPLLSPVL PLLFGLLLLA LAALHVVVCT
AVDSSCYLCG LPWLAAGGVM ALTAALLCAG VSALTRIFAG GQCLTQTPPQ STSRWSELGL
LSFLGTVGHV LSLGASSFIE EEHQTWYFLI NTLCLALCHQ IYRHCFLGDD CAPQRCPHTG
EEFDGVAVAR QGKRAGPEGW ELSHAPKDPS SLEALRGPER WMVLASPWLV LACCRLLRSL
NQTGVQWAHR PDLGHWLTSS DHKAELSVLA ALSLTMIFVL VQKRCSLTSK VAVAFGLLGI
YCYRAAIGNV LFPWQQDNKD ISKGITEARF VYVFVLGILF TGTKDLLKSQ IIAADFTART
VGLWEIHSGL VLLAALLLRP HNLPVLVLSL TVQTVMTQFI WRPLRHGAAA VTVMHYWFGQ
AFFYFQGNSN SIATVDISAG FVGLDAYMEI PAMFLTAFAT YSGPVLWASH LVNFLTSEAS
SGSALRRACF CYALVCSVPV SVYIVMVTSL RYHLFIWSVF SPKLLYEGMH LLITAAVCIF
FTAMDQTNTK S
//