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Database: UniProt
Entry: W5Q6M2_SHEEP
LinkDB: W5Q6M2_SHEEP
Original site: W5Q6M2_SHEEP 
ID   W5Q6M2_SHEEP            Unreviewed;       971 AA.
AC   W5Q6M2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=GPI ethanolamine phosphate transferase 2 {ECO:0000256|ARBA:ARBA00020830};
GN   Name=PIGG {ECO:0000313|Ensembl:ENSOARP00000018363.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018363.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000018363.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018363.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000018363.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC       biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
CC       {ECO:0000256|ARBA:ARBA00005315}.
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DR   EMBL; AMGL01101179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01101180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01101181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012035846.1; XM_012180456.1.
DR   AlphaFoldDB; W5Q6M2; -.
DR   SMR; W5Q6M2; -.
DR   STRING; 9940.ENSOARP00000018363; -.
DR   PaxDb; 9940-ENSOARP00000018363; -.
DR   Ensembl; ENSOART00000018625.1; ENSOARP00000018363.1; ENSOARG00000017110.1.
DR   eggNOG; KOG2125; Eukaryota.
DR   HOGENOM; CLU_004770_4_0_1; -.
DR   OMA; RVKFGHD; -.
DR   UniPathway; UPA00196; -.
DR   Proteomes; UP000002356; Chromosome 6.
DR   Bgee; ENSOARG00000017110; Expressed in abdominal lymph node and 55 other cell types or tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR   CDD; cd16024; GPI_EPT_2; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR002591; Phosphodiest/P_Trfase.
DR   InterPro; IPR037674; PIG-G_N.
DR   InterPro; IPR039527; PIGG/GPI7.
DR   InterPro; IPR045687; PIGG/GPI7_C.
DR   PANTHER; PTHR23072:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2; 1.
DR   PANTHER; PTHR23072; PHOSPHATIDYLINOSITOL GLYCAN-RELATED; 1.
DR   Pfam; PF01663; Phosphodiest; 1.
DR   Pfam; PF19316; PIGO_PIGG; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        420..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        453..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        490..518
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        713..734
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        749..767
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        776..797
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        866..888
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        909..932
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        944..964
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          642..954
FT                   /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19316"
SQ   SEQUENCE   971 AA;  106757 MW;  282EE9EE80E6FBC4 CRC64;
     MCRCDSACAG EVGRKQILRF LDAKNECKIQ FPFSFSNTLG ASSNWTELPP PLFSKVVIML
     IDALRDDFVF GSKGVKFMPY TTYLVEKGSS LSFVAEAKPP TVTMPRIKAL LTGSLPGFID
     VVRNLNSPTL LEDNVITRAK AAGKRIIFYG DETWVKLFPK HFVEYDGTTS FFVSDYTEVD
     NNVTRHLDKV LKRQDWDVLI LHYLGLDHIG HISGPSSPLI GPKLSEMDSI LMKIHTSLLS
     EERGALLPSL LALCGDHGMS EAGGHGASSM EEVNTALVLI SSAFERKPGD VRHPTHVQQT
     DLAATLSVGL GLPIPKSNTG SLLFRVVEGR PVREQLRLLH LNTVQLSKLL QENVPSYKKE
     PGFEQFKVAE RLHRSWVRLY LEGSNSEALA NLGAKVRRQY LDALRMLRLS LTRRAAQYDV
     YSMAVGTVLV LEALALLLLG VPQALSSRAE LDVPLLSPVL PLLFGLLLLA LAALHVVVCT
     AVDSSCYLCG LPWLAAGGVM ALTAALLCAG VSALTRIFAG GQCLTQTPPQ STSRWSELGL
     LSFLGTVGHV LSLGASSFIE EEHQTWYFLI NTLCLALCHQ IYRHCFLGDD CAPQRCPHTG
     EEFDGVAVAR QGKRAGPEGW ELSHAPKDPS SLEALRGPER WMVLASPWLV LACCRLLRSL
     NQTGVQWAHR PDLGHWLTSS DHKAELSVLA ALSLTMIFVL VQKRCSLTSK VAVAFGLLGI
     YCYRAAIGNV LFPWQQDNKD ISKGITEARF VYVFVLGILF TGTKDLLKSQ IIAADFTART
     VGLWEIHSGL VLLAALLLRP HNLPVLVLSL TVQTVMTQFI WRPLRHGAAA VTVMHYWFGQ
     AFFYFQGNSN SIATVDISAG FVGLDAYMEI PAMFLTAFAT YSGPVLWASH LVNFLTSEAS
     SGSALRRACF CYALVCSVPV SVYIVMVTSL RYHLFIWSVF SPKLLYEGMH LLITAAVCIF
     FTAMDQTNTK S
//
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