ID W5Q6N3_SHEEP Unreviewed; 472 AA.
AC W5Q6N3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Platelet glycoprotein 4 {ECO:0000256|ARBA:ARBA00020772};
DE AltName: Full=Glycoprotein IIIb {ECO:0000256|ARBA:ARBA00032780};
DE AltName: Full=PAS IV {ECO:0000256|ARBA:ARBA00031821};
DE AltName: Full=PAS-4 {ECO:0000256|ARBA:ARBA00032188};
DE AltName: Full=Platelet glycoprotein IV {ECO:0000256|ARBA:ARBA00029966};
GN Name=LOC101115115 {ECO:0000313|Ensembl:ENSOARP00000018374.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018374.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018374.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018374.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018374.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in);
CC Xref=Rhea:RHEA:33655, ChEBI:CHEBI:30823;
CC Evidence={ECO:0000256|ARBA:ARBA00000626};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33656;
CC Evidence={ECO:0000256|ARBA:ARBA00000626};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-
CC octadecadienoate(in); Xref=Rhea:RHEA:45264, ChEBI:CHEBI:30245;
CC Evidence={ECO:0000256|ARBA:ARBA00000542};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45265;
CC Evidence={ECO:0000256|ARBA:ARBA00000542};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=butanoate(out) = butanoate(in); Xref=Rhea:RHEA:45248,
CC ChEBI:CHEBI:17968; Evidence={ECO:0000256|ARBA:ARBA00001892};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45249;
CC Evidence={ECO:0000256|ARBA:ARBA00001892};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoate(out) = hexadecanoate(in); Xref=Rhea:RHEA:45256,
CC ChEBI:CHEBI:7896; Evidence={ECO:0000256|ARBA:ARBA00000934};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45257;
CC Evidence={ECO:0000256|ARBA:ARBA00000934};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=tetracosanoate(out) = tetracosanoate(in);
CC Xref=Rhea:RHEA:45260, ChEBI:CHEBI:31014;
CC Evidence={ECO:0000256|ARBA:ARBA00023949};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45261;
CC Evidence={ECO:0000256|ARBA:ARBA00023949};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=tetradecanoate(out) = tetradecanoate(in);
CC Xref=Rhea:RHEA:45252, ChEBI:CHEBI:30807;
CC Evidence={ECO:0000256|ARBA:ARBA00000996};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45253;
CC Evidence={ECO:0000256|ARBA:ARBA00000996};
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004221}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00004285}.
CC -!- SIMILARITY: Belongs to the CD36 family.
CC {ECO:0000256|ARBA:ARBA00010532}.
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DR EMBL; AMGL01086845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01086846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01086847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012031972.1; XM_012176582.2.
DR RefSeq; XP_012031973.1; XM_012176583.2.
DR RefSeq; XP_012031974.1; XM_012176584.2.
DR RefSeq; XP_012031975.1; XM_012176585.1.
DR RefSeq; XP_012031976.1; XM_012176586.2.
DR RefSeq; XP_012031977.1; XM_012176587.2.
DR AlphaFoldDB; W5Q6N3; -.
DR SMR; W5Q6N3; -.
DR STRING; 9940.ENSOARP00000018374; -.
DR PaxDb; 9940-ENSOARP00000018374; -.
DR Ensembl; ENSOART00000018636.1; ENSOARP00000018374.1; ENSOARG00000017123.1.
DR eggNOG; KOG3776; Eukaryota.
DR HOGENOM; CLU_019853_0_0_1; -.
DR OMA; AFQNWLV; -.
DR Proteomes; UP000002356; Chromosome 4.
DR Bgee; ENSOARG00000017123; Expressed in heart right ventricle and 54 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR005428; CD36/SCARB1/SNMP1.
DR InterPro; IPR002159; CD36_fam.
DR PANTHER; PTHR11923:SF12; PLATELET GLYCOPROTEIN 4; 1.
DR PANTHER; PTHR11923; SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1; 1.
DR Pfam; PF01130; CD36; 1.
DR PRINTS; PR01610; CD36ANTIGEN.
DR PRINTS; PR01609; CD36FAMILY.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR605428-52};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499,
KW ECO:0000256|PIRSR:PIRSR605428-51};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843,
KW ECO:0000256|PIRSR:PIRSR605428-51}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT SITE 463
FT /note="Critical for TLR4-TLR6 dimerization and signaling"
FT /evidence="ECO:0000256|PIRSR:PIRSR605428-50"
FT DISULFID 243..311
FT /evidence="ECO:0000256|PIRSR:PIRSR605428-52"
FT DISULFID 272..333
FT /evidence="ECO:0000256|PIRSR:PIRSR605428-52"
FT DISULFID 313..322
FT /evidence="ECO:0000256|PIRSR:PIRSR605428-52"
FT CROSSLNK 469
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000256|PIRSR:PIRSR605428-51"
SQ SEQUENCE 472 AA; 52828 MW; DC1D7BB4E9153CEC CRC64;
MGCNRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKK EVVLEDGTIA FKNWVKTGTD
VYRQFWIFDV QNPDEVAVNS SKIKVKQRGP YTYRVRYLAK ENITQDPETH TVSFLQPNGA
IFEPSLSVGT EDDTFTILNL AVAAVPHLYP NSFIQGILNS LIKKSKSSMF QNRTLKELLW
GYTDPFLNLV PYPVTTTVGV FYPYNNTADG IYKVFNGKDD ISKVAIIDTY KGRKNLSYWS
SYCDLINGTD AASFPPFVEK TRKLQFFSSD ICRSIYAVFG AELNLKGIPV YRFVLPSLAF
ASPLQNPDNH CFCTEKLLSK NCTLYGVLDI SKCKEGKPVY ISLPHFLHGS PELAEPIEGL
SPNEEEHSTY LDVEPITGFT LRFAKRLQIN ILVKPARKID ALKNLKHNYI VPILWLNETG
TIGDEKAEMF RKQVTGKINL LGLVEMVLLS VGVVMFIAFM ISYCACRSKR VN
//
