ID W5Q6Q7_SHEEP Unreviewed; 261 AA.
AC W5Q6Q7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=VAMP associated protein B and C {ECO:0000313|Ensembl:ENSOARP00000018398.1};
GN Name=VAPB {ECO:0000313|Ensembl:ENSOARP00000018398.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018398.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018398.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018398.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018398.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004163}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17)
CC family. {ECO:0000256|ARBA:ARBA00008932}.
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DR EMBL; AMGL01025712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012044310.1; XM_012188920.2.
DR AlphaFoldDB; W5Q6Q7; -.
DR SMR; W5Q6Q7; -.
DR STRING; 9940.ENSOARP00000018398; -.
DR PaxDb; 9940-ENSOARP00000018398; -.
DR Ensembl; ENSOART00000018660.1; ENSOARP00000018398.1; ENSOARG00000017143.1.
DR eggNOG; KOG0439; Eukaryota.
DR HOGENOM; CLU_032848_0_1_1; -.
DR OMA; AENAKPH; -.
DR Proteomes; UP000002356; Chromosome 13.
DR Bgee; ENSOARG00000017143; Expressed in cardiac muscle tissue of left auricle and 54 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like_sf.
DR InterPro; IPR016763; VAP.
DR PANTHER; PTHR10809; VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR10809:SF12; VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN B/C; 1.
DR Pfam; PF00635; Motile_Sperm; 1.
DR PIRSF; PIRSF019693; VAMP-associated; 1.
DR SUPFAM; SSF49354; PapD-like; 1.
DR PROSITE; PS50202; MSP; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT TRANSMEM 242..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..142
FT /note="MSP"
FT /evidence="ECO:0000259|PROSITE:PS50202"
FT REGION 205..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 261 AA; 28898 MW; 3201174757EDFE15 CRC64;
MIMSQPRSTS VLTPYHKSVF PPHGPHGIPN QSLSHSAGPF TDVVTTNLKL GNPTDRNVCF
KVKTTAPRRY CVRPNSGIID AGASINVSVM LQPFDYDPNE KSKHKFMVQS MFAPTDTSDM
EAVWKEAKPE DLMDSKLRCV FELPAENDKP HDVEINKIIP TTTSKTETPT VSKALSSSLD
DTEVKKVMEE CKRLQSEVQR LREENKQFKE EDGLRMRKTV QSNSPAPASA AAGKEEGLST
RLLALVVLFF IVGVIIGKIA L
//