ID W5Q7M1_SHEEP Unreviewed; 655 AA.
AC W5Q7M1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Ribosomal RNA-processing protein 8 {ECO:0000256|ARBA:ARBA00020203};
GN Name=RRP8 {ECO:0000313|Ensembl:ENSOARP00000018713.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018713.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018713.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018713.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018713.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RRP8 family.
CC {ECO:0000256|ARBA:ARBA00006301}.
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DR EMBL; AMGL01032142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q7M1; -.
DR SMR; W5Q7M1; -.
DR STRING; 9940.ENSOARP00000018713; -.
DR PaxDb; 9940-ENSOARP00000018713; -.
DR Ensembl; ENSOART00000018977.1; ENSOARP00000018713.1; ENSOARG00000017435.1.
DR eggNOG; KOG3045; Eukaryota.
DR HOGENOM; CLU_027694_2_3_1; -.
DR OMA; QNQVKKW; -.
DR Proteomes; UP000002356; Chromosome 15.
DR Bgee; ENSOARG00000017435; Expressed in thymus and 56 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.10.2150; Ribosomal RNA-processing protein 8, N-terminal domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR007823; RRP8.
DR InterPro; IPR042036; RRP8_N.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR PANTHER; PTHR12787:SF0; RIBOSOMAL RNA-PROCESSING PROTEIN 8; 1.
DR PANTHER; PTHR12787; UNCHARACTERIZED; 1.
DR Pfam; PF05148; Methyltransf_8; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01184; UBIE_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..139
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..400
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 71828 MW; 56B5D4E0996B500A CRC64;
APGFVPYRRE KGGSGEVGVD EEVVSSEGMS REQAQRPYPR TELGGGGGEF RRRIPWRRGG
PCRGWPSFPT RNRVGGGRGD RLVKLEPWGG GTGAPTLTGT RARGAFSGEL PSGRARRPAP
PLALSGQRGP PSPVPSLPPS LPFPPVSKLD GFRHCAGCSS HFSSHSLVSC PVPASLSETW
SARGEAGGSR NLALPSPMFE EPEWAEEAPV VADLGSVALG LRPTATSQIK GANRRQLLAT
LRALEVASVP QQPPSLPGSD SEEEEEVVET KKKRTKKGLF AGASSEVEEK RKKKRHKQGP
PSSDSKEEEV ERKKCHKGVL LGSDLAEEEK KRRKCQKQIP SNLAQPLDSV DQTDSKAWNS
SATSDLTKPT CETPSSNPPH TLSRKQWRNR QKNKRRQKNK FRPSQPPEQA PAPASAEEAE
VPSAPSPDSH GARAEALRAR MAQRLDGARF RYLNEQLYSG PSSAAQRLFQ EDPEAFLLYH
RGFQNQVKKW PLQPVDRIAR DLRQRPASLV VADFGCGDCR LASSIRNRVH CFDLASLDPR
VTVCDMAQVP LEDESIDVAV FCLSLMGTNI RDFLEEANRV LKPGGFLKVA EVSSRFEDVR
TFLGAVTKLG FKVISKDLTN SHFFLFDFEK TGPPRVGPKT QLSGLKLQPC LYKRR
//
