ID W5Q7Q8_SHEEP Unreviewed; 744 AA.
AC W5Q7Q8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=RUN and TBC1 domain-containing protein 3 {ECO:0000256|ARBA:ARBA00030864};
GN Name=SGSM3 {ECO:0000313|Ensembl:ENSOARP00000018750.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018750.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018750.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018750.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018750.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the small G protein signaling modulator family.
CC {ECO:0000256|ARBA:ARBA00006296}.
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DR EMBL; AMGL01083994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01083995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01083996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q7Q8; -.
DR SMR; W5Q7Q8; -.
DR STRING; 9940.ENSOARP00000018750; -.
DR PaxDb; 9940-ENSOARP00000018750; -.
DR Ensembl; ENSOART00000019016.1; ENSOARP00000018750.1; ENSOARG00000017466.1.
DR eggNOG; KOG2222; Eukaryota.
DR HOGENOM; CLU_020721_0_0_1; -.
DR OMA; QKWYQPW; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000017466; Expressed in metanephros cortex and 51 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd17688; RUN_SGSM3; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF19; RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF02759; RUN; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 189..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 111..311
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 478..539
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 555..720
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
SQ SEQUENCE 744 AA; 83922 MW; 25AD3A6B9E1032CA CRC64;
LLGSHVPSAN GPFSALTPSM WPQEILAKCA QEEAAEEQPE VRYDEFGFRV DKEDADGTPY
SGQLLEDPPQ RLRWQAHLEF THNHDVGDLT WDKIAVSLPR SEKLRSLVLA GVPHSMRPQL
RMLLSGALQK KRNSELSYRE IVKNSSNDET IAAKQIEKDL LRTMPSNACF AHVSGVGVPR
LRRVLRALAW LYGAGGWHMV CGVVAACLLL FLEEDDAFWM MCAIIEDLLP ASYFSTTLLG
VQTDQRVLRQ QPARRVLRHL IVQYLPRLDR LLQEHDIELS LITLHWFLTA FASVVHIRLL
LRLWDLFFYE GSLVLFQATL GMLRLKEDEL IQSENSASIF NTLSDIPSQL EDADLLLAEA
MRLAGSLTAL AVEAQRRKHL AYLLADQGQL LGPPQPASLS QVVRRRTQRR KAGITSLLFG
GRALGWALKV WGMCTRNHSP GSVHKGGVVE GRRHCQFTDP NNCNGELTPD YSMESHQRDH
ENYVACSRGH PRRATALELG FRKNDIITIV SQKDEHCWVG ELNGLRGWFP AKFVEVLDER
SKEYSIAGDD AVTEGVTDLV RGTLCPALKA LFEHGLKKPS LLGGACHPWL FIEEAAGREV
ERDFDSVYSR LVLCKTYRLD EDGKVLTPEE LLYRAVQSVN VTHDAAHAQM DVKLRSLICV
GLNEQVLHLW LEVLCSSLPT VEKWYQPWAF PRSPGWVQIK CELRLQCGFH SLCPAAVTEE
KKPLKEGVQD MLVKHHLFSW DIDG
//
