ID W5Q7Z7_SHEEP Unreviewed; 2748 AA.
AC W5Q7Z7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Desmoplakin {ECO:0000313|Ensembl:ENSOARP00000018839.1};
GN Name=DSP {ECO:0000313|Ensembl:ENSOARP00000018839.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018839.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018839.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018839.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, desmosome
CC {ECO:0000256|ARBA:ARBA00004568}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004236}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AMGL01059765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01059766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; W5Q7Z7; -.
DR STRING; 9940.ENSOARP00000018839; -.
DR PaxDb; 9940-ENSOARP00000018839; -.
DR Ensembl; ENSOART00000019105.1; ENSOARP00000018839.1; ENSOARG00000017552.1.
DR eggNOG; KOG0516; Eukaryota.
DR HOGENOM; CLU_000679_1_0_1; -.
DR OMA; GIRQQVT; -.
DR Proteomes; UP000002356; Chromosome 20.
DR Bgee; ENSOARG00000017552; Expressed in omasum and 53 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 3.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR23169:SF26; DESMOPLAKIN; 1.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF00681; Plectin; 8.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR SMART; SM00250; PLEC; 17.
DR SMART; SM00150; SPEC; 2.
DR SUPFAM; SSF75399; Plakin repeat; 4.
DR SUPFAM; SSF46966; Spectrin repeat; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 404..461
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT COILED 357..387
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 975..1221
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1254..1295
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1343..1685
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1711..1867
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2748 AA; 317879 MW; AAB6CA8059555D51 CRC64;
FSQTGTMSRH QNQNTIQELL QNCSDCLMRA ELIVQPELKY GDGIQLARSR ELDECFAQAN
DQMEITDSLI REMRQMGQPC DAYQKRLLQL QEQMRALYKA ISAPRVRRAS SKGGGGYTCQ
SGSGWDEFTK RLTSECLGWM RQQRSEIEVM EMQIRKIISA QPILRWGQKC HHQASEICLQ
TDWEKSLWRE KSAIYQLEEE YENLLKASFE RMDHLRQLQN IIQATSREIM WINDCEEEEL
LYDWSDRNTN IAQKQEAFSI RMSQLEVKEK ELNKLKQESD QLVLNQHPAS DKIEAYMDTL
QTQWSWILQI TKCIDVHLKE NAAYFQFFEE AQSTEAYLKG LQDSIRKKYP CDKNTPLQRL
LEQIKELERE REKILEYKRQ VQSLVNKSKK IVQLKPRNPD YRSNKPIILR ALCDYKQDQK
IVHKGDECIL KDNNERSKWY VTGPGGVDML VPSVGLIIPP PNPLAVDLSS KIEQYYEAIL
ALWNQLYINM KSLVSWHYCM IDIEKIKAMT IAKLKTMRQE DYMKTISDLE LHYQEFIRNS
QGSEMFGDDD KRKMQTQFTD AQKHYQTLVI QLPGHPQHQT VTTTEITHLG TCQDVNHNKV
IETNRENDKQ ETWMLIELQK IRRQMELCES RMALKNLLLA DQGSSHHITV KINELKESVD
QPSAGKASLM KDRKGQLSPN FRGSEKYCYL QNEVFGLFQK LENINGVTDG YLNSLCAVRA
LLQAILQTED MLKVYEARLT EEETVCLDLD KVEAYRCGLK KIKNDLNLKK SLLATMKTEL
QKAQQIHSQT SQQYPLYDLD LGKFSEKVTQ LTDRWQRIDK QIDYRLWDLE KQIKQLRNYR
DNYQAFCKWL YDAKRRQDSL ESMKFGDSNT VMRFLNEQKN LHSEISGKRD KSEEVQKIAE
LCANSIKDYE LQLASYTSGL ETLLSIPIKR TVIQSPSGVI LQEAADMHAR YIELLTRSGD
YYRFLSEMLK SLEDLKLKNT KIEVLEEELR LARDANSENC NKNKFLDQNL QKYQAECSQF
KAKLVSLEEL KRQAELDGKS AKQNLDKCYG QIKDLNEKIT RLTYEIEDEK RRRKAVEDRF
DQQKSDYDQL QKARQNEKES LGWQKMESEK AIKEKEFEIE RLRVLLQEEG ARKREYESEL
AKVRNHYNEE MSNLRNKYET EINITKTTIK EISMQKEDDS KNLRNQLDRL SRENRDLKEE
IVRLNDSILQ TTEQRRRAEE DALQQKACGS EMLQKKQHLE IELKQVIQQR SEDNARHKQS
LEEAAKTIQD KNKEIERLKA EFQEEAKRRW EYENELAKVR ANYDEEIISL KNQFETEINI
TKTTIHQLTL QKEEDTSGYR AQIDTLTREN RSLSEEVKRL KNTLAQTTET LRRVEENVQQ
QKTTGLEMSQ RKQQLEIELR QVTQMRTEES ARYKQSLDDA AKTIQDKNKE IDRLKQLIET
EASQRKCLED ENARLQRAQG ELQKAHSSAT ETISKLKVQE QELLRLRLDY ERVSQERTVR
DQDIARFQTS LKELQLQKQK AEEELARLKR AASEDSSKRK KLEEELEGLR RTLKEQAIKV
TSLTQQLEQA SIVKKRSEDE LRQQRDVLDG HLREKQRTQD ELRRLASEAE ALRRQLLQEQ
ESVRQAQARN EHFQKAIEDK SRSLNESKIE IERLQSLTES LTKEHLMLEE ELRQLRLEYD
DLRRGRSEAD HDKNATIAEL RSQLQISNNR TLELQGLIND LQRERENLRQ EIERFQKQAL
EASNRIQESK NQCTQVVQER ESLLVKIKVL EQDKARLQRL EEELSRAKTA LEAESRVKQR
LECEKQQIQN DLNQWKTQYS RKEEAIRKIE SEREKSEREK NSLRSEIERL QAEIKRIEER
CRRKLEDSSR ETQSQLETER CRLQREIDRL KQRPYGSHRE TQTEYEWSVD SSKLVFDGLR
KKVTAVQLHE CQLIDKATLD KLLKGKKSVE EVASELQPFL RGAGAIAGAS ASPKEKYSLV
EAKRKKLITP ESTVMLLEAQ AATGGIIDPH RNEKLTVDNA IARDLIDFDD RQQIYTAEKA
VTGFDDPFSG KTVSVSEAIK KNLIDRETGM RLLEAQIASG GVVDPVNSVF LPKDVALARG
LIDRDLYRSL NDPRDSQKNF VDPVTKKKVS YMQLRERCRI EPHTGLLLLS VQKRSMSFQG
IRQPVTVSEL VDSGILRPST VNELESGQIS YDEVGERIKD FLQGSSCIAG IYNETTKQKL
GIYEAMKIGL VRPGTALELL EAQAATGFIV DPVSNLRLPV EEAYKRGLVG IEFKEKLLSA
ERAVTGYNDP ETGNIISLFQ AMNKELIEKG HGIRLLEAQI ATGGIIDPKE SHRLPVDIAY
KRGYFNEELS EILSDPSDDT KGFFDPNTEE NLTYLQLKER CIKDEETGLC LLPLKEKKKQ
VQTSQKNTLR KRRVVIVDPE TNKEMSVQEA YKKGLIDYDT FKELCEQECE WEEITITGSD
GSTRVVLVDR KTGSQYDIQD TIDKGLIDRK FFEQYRSGSL SLTQFADMIS LKNGVGSGVG
GGMGGGVGGS SSTGGGLSDD VFGGSRHETV SKISTISSIR NLTIRSSSLS EPLEESSPIA
AIFDTENLEK ISISEGIERG IVDSISGQRL LEAQACTGGI IHPTTGQKLS LQDAVSQGLI
DQDMATRLKP AQKAFIGFEG VKGKKKMSAA EAVKEKWLPY EAGQRFLEFQ YLTGGLVDPE
VQGRISMEEA IRKGYIDGRA AQRLQDTSTY GKILTCPKTK LKISYKDA
//