ID W5Q8E6_SHEEP Unreviewed; 400 AA.
AC W5Q8E6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=POU domain protein {ECO:0000256|RuleBase:RU361194};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000018988.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000018988.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000018988.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000018988.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family.
CC {ECO:0000256|RuleBase:RU361194}.
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DR EMBL; AMGL01088453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01088454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01088455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q8E6; -.
DR SMR; W5Q8E6; -.
DR STRING; 9940.ENSOARP00000018988; -.
DR PaxDb; 9940-ENSOARP00000018988; -.
DR Ensembl; ENSOART00000019256.1; ENSOARP00000018988.1; ENSOARG00000017698.1.
DR eggNOG; KOG3802; Eukaryota.
DR HOGENOM; CLU_013065_6_0_1; -.
DR OMA; LXISAAS; -.
DR Proteomes; UP000002356; Chromosome 4.
DR Bgee; ENSOARG00000017698; Expressed in cardiac muscle tissue of left auricle and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR PANTHER; PTHR11636; POU DOMAIN; 1.
DR PANTHER; PTHR11636:SF68; POU DOMAIN, CLASS 6, TRANSCRIPTION FACTOR 2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 2.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361194};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 185..295
FT /note="POU-specific"
FT /evidence="ECO:0000259|PROSITE:PS51179"
FT DOMAIN 314..374
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 316..375
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 141..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 400 AA; 42754 MW; 616B29C9D5A9FE87 CRC64;
LQLVNNPLAS QAAAAAAAAA MGSIASSQAF GNTLSSLQGV TGQLVTNAQG QIIGTIPLMP
NPGPSSQTAS GTQGLQVQPI TPQLLTNAQG QIIATVIGNQ ILPVINTQGI TLSPIKPGQQ
LHQPSQTSVG QAASQSSLLH LAHSQASMSQ SPVRQASSSS SSSSSSSALS VGQLVSNPQT
AAGEVDGVNL EEIREFAKAF KIRRLSLGLT QTQVGQALSA TEGPAYSQSA ICRHTILRSH
FFLPQEAQEN TIASSLTAKL NPGLLYPARF EKLDITPKSA QKIKPVLERW MAEAEARHRA
GMQNLTEFIG SEPSKKRKRR TSFTPQALEI LNAHFEKNTH PSGQEMTEIA EKLNYDREVV
RVWFCNKRQA LKNTIKRLKQ HEPATAVPLE PLTDSLEENS
//
