ID W5Q960_SHEEP Unreviewed; 447 AA.
AC W5Q960;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Zinc finger protein 3 {ECO:0008006|Google:ProtNLM};
GN Name=ZNF3 {ECO:0000313|Ensembl:ENSOARP00000019252.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019252.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000019252.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019252.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000019252.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01069487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004021088.1; XM_004021039.2.
DR AlphaFoldDB; W5Q960; -.
DR SMR; W5Q960; -.
DR STRING; 9940.ENSOARP00000019252; -.
DR PaxDb; 9940-ENSOARP00000019252; -.
DR Ensembl; ENSOART00000019520.1; ENSOARP00000019252.1; ENSOARG00000017937.1.
DR GeneID; 101110990; -.
DR KEGG; oas:101110990; -.
DR CTD; 7551; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_44_3_1; -.
DR OMA; MGDRPHK; -.
DR OrthoDB; 4624799at2759; -.
DR Proteomes; UP000002356; Chromosome 24.
DR Bgee; ENSOARG00000017937; Expressed in gastric lymph node and 53 other cell types or tissues.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24381; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24381:SF410; ZINC FINGER PROTEIN 3; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 52..124
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 201..228
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 229..256
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 257..284
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 285..312
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 313..340
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 341..368
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 369..396
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 397..424
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 50414 MW; 60E01CE981595A0E CRC64;
METQADRVSQ EPQALLESTL PSSKGPAFSD KGGLGDEMLA AALLKAKAQE LVTFEDVAVY
FIRKEWKRLE PAQRDLYRDV MLENYGNVFS LDGETRTEPD SEISEDRGSH GVLLGRFQKD
ISQGLKFEEA YEQEVSLKRQ LGSSSGERLN RKMQEFGQVA AEEQRAPTGG RSEKCGDLRD
SFTVGANLIS HQRLPVGDRP HKCDECSKSF NRTSDLIQHQ RIHTGEKPYE CSECGKAFSQ
SSHLIQHQRI HTGEKPYECN DCGKTFSCSS ALILHRRIHT GEKPYECNEC GKTFSWSSTL
THHQRIHTGE KPYACNECGK AFSRSSTLIH HQRIHTGEKP YECNECGKAF SQSSHLYQHQ
RIHTGEKPYE CMECGGKFTY SSGLIQHQRI HTGENPYECS ECGKAFRYSS ALVRHQRIHT
GEKPLNVMGV SKSSLQVTAE VNIREST
//
