ID W5Q9K5_SHEEP Unreviewed; 165 AA.
AC W5Q9K5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Transcription factor HES-5 {ECO:0008006|Google:ProtNLM};
GN Name=HES5 {ECO:0000313|Ensembl:ENSOARP00000019397.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019397.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000019397.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019397.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000019397.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AMGL01021892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004013819.1; XM_004013770.3.
DR AlphaFoldDB; W5Q9K5; -.
DR SMR; W5Q9K5; -.
DR STRING; 9940.ENSOARP00000019397; -.
DR PaxDb; 9940-ENSOARP00000019397; -.
DR Ensembl; ENSOART00000019667.1; ENSOARP00000019397.1; ENSOARG00000018071.1.
DR GeneID; 101103410; -.
DR KEGG; oas:101103410; -.
DR CTD; 388585; -.
DR eggNOG; ENOG502S6S1; Eukaryota.
DR HOGENOM; CLU_068550_3_1_1; -.
DR OMA; EVQTQAH; -.
DR OrthoDB; 2961710at2759; -.
DR Proteomes; UP000002356; Chromosome 12.
DR Bgee; ENSOARG00000018071; Expressed in embryo and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11461; bHLH-O_HES5; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF104; TRANSCRIPTION FACTOR HES-5; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 16..72
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 89..120
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 127..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 165 AA; 18146 MW; D4D4DBF4ABC6BB73 CRC64;
MAPSTVAVEL LSPKEKNRLR KPVVEKMRRD RINSSIEQLK LLLEQEFARH QPNSKLEKAD
ILEMAVSYLK HSKAFAAAAA GPKSLHQDYS EGYSWCLQEA VQFLTLHAAS DTQMKLLYHF
QRPPAATAAP AKEPKAPSPA PAPAPAKAAA AAVARQPACG LWRPW
//
