ID W5Q9N5_SHEEP Unreviewed; 1035 AA.
AC W5Q9N5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Toll like receptor 8 {ECO:0000313|Ensembl:ENSOARP00000019427.1};
GN Name=TLR8 {ECO:0000313|Ensembl:ENSOARP00000019427.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019427.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000019427.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019427.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000019427.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; AMGL01113776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q9N5; -.
DR SMR; W5Q9N5; -.
DR STRING; 9940.ENSOARP00000019427; -.
DR PaxDb; 9940-ENSOARP00000019427; -.
DR Ensembl; ENSOART00000019697.1; ENSOARP00000019427.1; ENSOARG00000018099.1.
DR eggNOG; KOG4641; Eukaryota.
DR HOGENOM; CLU_006000_2_0_1; -.
DR OMA; LSWNCYF; -.
DR Proteomes; UP000002356; Chromosome X.
DR Bgee; ENSOARG00000018099; Expressed in gastric lymph node and 48 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF1; TOLL-LIKE RECEPTOR 8; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 16.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1035
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004870028"
FT TRANSMEM 821..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 872..1016
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1035 AA; 118664 MW; 1C962B14BB6E307F CRC64;
ENMTLRFLLL TSLFLLISDS CEFFTEASYP RSYPCDVKNK NGSFIAECNS RRLQEVPQTV
DKAVTEVDLS DNFITRITNE SFQGLQNLTK INLNHNAKSQ SGNPAVKKAM TITYGAFLNL
KHLRELLLED NQLQEIPAGL PESLKELSLI QNNIITLTKK NTSGLGNLER LYLGWNCYFA
CNKKFSIENG AFQNLTKLKV LSLSFNPLHS VPPSLPSSLT ELYLSNTHIG NVSEEDFKEL
SNLRVLDLSG NCPRCFNAPF PCVPCQGGAS IQIHPLAFQT LTQLRYLNLS STSLRKVPAS
WFDNMHNLKV LDLEFNYLMD EIASGEFLTK LPSLEILDLS YNYELKKYPQ YINISKNFSK
LISLQMLHLR GYVFQELRRK DFKPLQHLSN LTTINLGVNF IKQIDFSIFH WFPNLKIVYL
SENRISPLVS DTEQHDANGT FFQSHILKRR SADIQFDPHS NFYHNTHPLI KTECSRLGNA
LDLSLNSIFF IGVNQFKDFG NISCLNLSSN GNGQVLNGTE FSRLSGIKYL DLTNNRLDFD
DDAAFSELPL LEVLDLSYNA HYFRIAGVTH RLGFIEHLTN LRVLNLSNND IFTLTETQLK
SASLGELVFS GNRLDLLWNA QDVRYWQIFQ NLTNLTRLDL ARNNLQHISS QAFLNLPRTL
TDLYINDNML NFFNWSLLEY FPHLRLLDLS GNQLFFLTNS LSTFASSLET LLLSRNRISH
LPSDFLSGAS SLIHLDLSSN QLKMLNRSTF ETKTATKLTI LELGSNPFDC TCDFGDFREW
MDRNLNVRVP RLTDVICASP GDQEGKSIVS LDLTTCVSDT IAAIFCFLTF SVTISVMLAA
LAHHWFYWDA WFIYHVCLAK VKGYRSLSTS QTFYDAYVSY DTKDASVTDW VINELRFHLE
ESEDKNVLLC LEERDWDPGL AIIDNLMQSI NQSKKTIFVL TKKYAKNWNF KTAFYLALQR
LMEENMDVIV FILLEPVLQH SQYLRLRQRI CKSSILQWPD NPKAEGLFWQ SLKNVVLTAN
DSRYNNLYVN SIKQY
//
