ID W5QAM3_SHEEP Unreviewed; 867 AA.
AC W5QAM3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Leucine-rich repeat-containing protein 66 {ECO:0008006|Google:ProtNLM};
GN Name=LRRC66 {ECO:0000313|Ensembl:ENSOARP00000019768.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000019768.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000019768.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000019768.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000019768.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01098521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01098522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QAM3; -.
DR SMR; W5QAM3; -.
DR STRING; 9940.ENSOARP00000019768; -.
DR PaxDb; 9940-ENSOARP00000019768; -.
DR Ensembl; ENSOART00000020041.1; ENSOARP00000019768.1; ENSOARG00000018415.1.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_016612_0_0_1; -.
DR OMA; NAYSNEG; -.
DR Proteomes; UP000002356; Chromosome 6.
DR Bgee; ENSOARG00000018415; Expressed in duodenum and 25 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF175; LEUCINE RICH REPEATS AND TRANSMEMBRANE DOMAINS 2; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..867
FT /note="Leucine-rich repeat-containing protein 66"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004871566"
FT TRANSMEM 372..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 463..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..867
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 96847 MW; 747351DF8746ABB5 CRC64;
MKNLCFRVIT MVIGLYFTDT MTNPSRKSSI LFNSNCQWNG YLTTNCSFAR KHEIPMDISQ
IAPTVDESSN FFRVLLQTHM KKEEWNIKHL DLSNNLISKI TLSSLEHFHA LEILNLSNNA
IHSVLLDLPS FKSSWVKRHR GSLRNRLPFL KLLILQRNKL SNIPKGLWKL KSLQSLDLSF
NRISQIGLSD FHNCLQLETL YLKSNRIFRI HPEAFKDLKN LQQMVDLSNN ALTAILPVVI
MALELPHLEA DLADNPWQCD YSLAVFQNVI SESWRKRWNA ICNESTGKED AHWWTPTSRM
ARETHLPQAD LKHMKTLIRS KAERAQEVRF SMLEKDTAGS DVGDRPRQLP KRVRRAEDVH
AAGRQADSSQ DLVLAVCLSV FITFFVAFCL GAFTRPYMDR LWQQRCRKKS PGSALGNEYS
NQAFYDEIEG AVNLQQPRMD LPQTFHHLNL YENQAPRAAV LPPRTVAPSR REAGGRQDRE
QRGVPTGAGS GKDTVPPNHS AARRVLYGPP NAHDTQLTSA GWDHVYRNDV PGEGNYDTVA
RQVSLGERSV GIPAVAARIQ TSPGSVRKDS DELGPPCPRE TTAPLSQRPA RAHAPSTGEE
RGGVPPHCRS ECSKENGQSA QQQRLQGAGA EGQPPAHYEA ATLSDPGDPS PLGGPPGCRG
ELTVTPAYQE PAQKHTPDAQ YEVDSDSESE EGSLFTLSST SSEDWRNVAK EEAGGEQSWR
AEEPPGDQVS YERRDSVRPL ESPEENITFQ KTLRKCENQE DHFGKTVVSD PDSHLCQTHL
ESASNTNNYE DPLPGLSGSS SSSEEVPSMS IYNYISALQP STVEWQYSLR DLEFANVDAL
PQTPPCSAKV PSDPDKVCRE GDTDVCK
//
