ID W5QC90_SHEEP Unreviewed; 622 AA.
AC W5QC90;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Zinc finger protein 786 {ECO:0008006|Google:ProtNLM};
GN Name=ZNF786 {ECO:0000313|Ensembl:ENSOARP00000020337.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000020337.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000020337.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000020337.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000020337.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AMGL01089764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01089765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01089766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01089767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000020337; -.
DR PaxDb; 9940-ENSOARP00000020337; -.
DR Ensembl; ENSOART00000020617.1; ENSOARP00000020337.1; ENSOARG00000018934.1.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_41_0_1; -.
DR OMA; TKSCRAP; -.
DR Proteomes; UP000002356; Chromosome 4.
DR Bgee; ENSOARG00000018934; Expressed in longissimus thoracis muscle and 54 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 10.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24390; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24390:SF246; ZINC FINGER PROTEIN 408; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 9..80
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 194..216
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 349..376
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 377..404
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 405..432
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 433..460
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 461..488
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 489..515
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 516..543
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 544..571
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 572..595
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 292..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 70407 MW; 268A657DCB8A993A CRC64;
QPFPAELPLT FEDVAIYFSE QEWQNLEAWQ KELYKQVMRA NYEILLSLDN GLPKPELISW
IEQGRELFKK WGESQESRNI IFSAADLHFD PVIEGQSFSG NQRAVSSEKA HYYFQVDPLQ
SHRSCEPLSE KSEDVSFRPD QAVALVNPQR HNTWAPLPAV HSSREPIQRD RIASPRALGL
PGFQKTASGE GLQQSCAFCG ESFCNENLLE RHQGSHLKAW KKLSKQPEAQ QPRSQTHFRC
PGCGRGFRRK PSLLGSLAVR AEESHLLGLE SGETCGRRLT LSRPPPYAGC IESASRAPPG
VERPVSPREG AGAASERAEL PPSSNLXLGF RLRSPLRAHG LRHGGDRPLA CGECGRGFAH
PCKLREHLRV HSGERPFGCA ECGKSFRLKG ILKAHERTHS RERPFQCAEC GRGFTRPSKL
AEHFRVHSGE RPFGCSDCGR RFRLQGQLRS HRRLHTGERP FPCPDCGKSY RVKADLKAHQ
LLHGGPMPFS CEGGKGFAKQ SKLVEHVRTH TGEKPFQCPQ CDKRFRLKAQ LLSHQGLHSG
ERPFRCPECD KNFRERGHML RHQRIHRPDR PFACADCGKG FIYKSKLAEH VRVHTKSCRV
RREPDVKKRL SQLFAMIEAD WS
//
