ID W5QCM1_SHEEP Unreviewed; 517 AA.
AC W5QCM1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=ADP-ribosylation factor GTPase-activating protein 3 {ECO:0000256|ARBA:ARBA00039243};
GN Name=ARFGAP3 {ECO:0000313|Ensembl:ENSOARP00000020468.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000020468.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000020468.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000020468.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000020468.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004255}.
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DR EMBL; AMGL01084109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01084110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01084111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01084112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01084113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004007079.1; XM_004007030.3.
DR AlphaFoldDB; W5QCM1; -.
DR Ensembl; ENSOART00000020751.1; ENSOARP00000020468.1; ENSOARG00000019057.1.
DR GeneID; 101115447; -.
DR KEGG; oas:101115447; -.
DR CTD; 26286; -.
DR HOGENOM; CLU_023062_6_2_1; -.
DR OrthoDB; 389572at2759; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000019057; Expressed in pituitary gland and 54 other cell types or tissues.
DR ExpressionAtlas; W5QCM1; baseline and differential.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd09028; ArfGap_ArfGap3; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR PANTHER; PTHR45686; ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED; 1.
DR PANTHER; PTHR45686:SF1; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 3; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}; Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 10..127
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 139..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 56868 MW; 81AFD962FF77B62C CRC64;
MGDPSKQDIL TIFKRLRSVP TNKVCFDCGA KNPSWASITY GVFLCIDCSG GHRSLGVHLS
FIRSTELDSN WSWFQLRCMQ VGGNANASSF FHQHGCDTND TNAKYNSRAA QLYRERIKGL
ASQATRKHGT DLWLDSCVVP PSSPPPKEED FFASHASPEV STTGWASAQP EPSLTPRNVD
TPPASSEGVP EQGPSVEGLN VPTKAAVGEV SSIIKKKPNQ AKRGLGAKKG SLGAQKLSNT
CFNEIEKQAQ AVDKMNAQED LLSRAAPKEE SIVSSLRLAY KDLEIQMKKD EKMNMSGKKK
AESERLGMGF GNSRSGISHS VTSDMQTIEQ ETPITAKPRK KYGDDSDDSY FTSSSRFFDE
PMELRSSSFS SWDDSSDSYW KKETIKDTDP IPKNTGYTDR PTTRRKPDYE PAENTDEAQK
KFGNVKAISS DMYFGRQAKA DYEARARLER LSASSSISSA DLFDEQRKQT AGSYNLTSVL
PTAPDMAQFK QGVRSVAGKL SVFANGVMTS IQDRYGS
//
