ID W5QCU7_SHEEP Unreviewed; 437 AA.
AC W5QCU7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=SOCS box domain-containing protein {ECO:0000259|PROSITE:PS50225};
GN Name=ASB18 {ECO:0000313|Ensembl:ENSOARP00000020545.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000020545.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000020545.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000020545.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000020545.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; AMGL01000536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01000537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01000538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01000539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01000540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01000541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01000542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QCU7; -.
DR Ensembl; ENSOART00000020828.1; ENSOARP00000020545.1; ENSOARG00000019126.1.
DR HOGENOM; CLU_035721_2_0_1; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000019126; Expressed in skeletal muscle tissue of biceps brachii and 8 other cell types or tissues.
DR ExpressionAtlas; W5QCU7; baseline.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03723; SOCS_ASB4_ASB18; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24118:SF76; ANKYRIN REPEAT AND SOCS BOX PROTEIN 18; 1.
DR PANTHER; PTHR24118; POTE ANKYRIN DOMAIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT REPEAT 90..122
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 122..154
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 155..187
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 189..221
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 263..295
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 392..428
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 437 AA; 47697 MW; D88D77797D105D69 CRC64;
MDRRPEPARG RLQIFQRMEK EPQARDGSPV LEYHATLATG DLEHLKPLMD KFFQDANVVF
EIKKDEMVWQ VKSPATFGLS GLWTLEYKRE LTTPLCIAAA QGHTACVRHL LGCGADPDAS
PGGRGALHEA CLGGHTACAR LLLQHRADPD LLSAEGLAPL HLCRTAASLG CAQALLEHGA
SVQLEGGASR DTPLHVAAQR GLDEHARLYL NHGARVDARN GRGETALSTA CGAAWRPNEQ
ARCLRLCALL LRHGAAADTR DEDERSPLHK ACGHARPSLA RLLLRHGADA RALDYGGASP
LARVLQTAAC APDAEPQLTV QELLNHGSPT VWPDAFPKVL KSCAAVPAVI EVLFNSYPQL
RISESWKEVI PEEVFQVHQA FYQALFALAH TPRCLQHLCR CAIRKSFGRK CFSLVPLLPL
PESLQNYLLL EPEGVLH
//
