ID W5QD02_SHEEP Unreviewed; 757 AA.
AC W5QD02;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Transmembrane 9 superfamily member {ECO:0000256|RuleBase:RU363079};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000020600.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000020600.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000020600.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000020600.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays an essential role in autophagy.
CC {ECO:0000256|ARBA:ARBA00037688}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane
CC {ECO:0000256|ARBA:ARBA00004542}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004542}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SNF7 family.
CC {ECO:0000256|ARBA:ARBA00006190}.
CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC {ECO:0000256|ARBA:ARBA00005227, ECO:0000256|RuleBase:RU363079}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363079}.
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DR EMBL; AMGL01102160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01102161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QD02; -.
DR SMR; W5QD02; -.
DR STRING; 9940.ENSOARP00000020600; -.
DR PaxDb; 9940-ENSOARP00000020600; -.
DR Ensembl; ENSOART00000020883.1; ENSOARP00000020600.1; ENSOARG00000019177.1.
DR eggNOG; KOG1277; Eukaryota.
DR eggNOG; KOG1656; Eukaryota.
DR HOGENOM; CLU_010714_3_0_1; -.
DR OMA; AKWKETD; -.
DR Proteomes; UP000002356; Chromosome 7.
DR Bgee; ENSOARG00000019177; Expressed in fallopian tube and 53 other cell types or tissues.
DR GO; GO:0000421; C:autophagosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007034; P:vacuolar transport; IEA:InterPro.
DR Gene3D; 6.10.250.1710; -; 1.
DR Gene3D; 1.10.287.1060; ESAT-6-like; 1.
DR InterPro; IPR004240; EMP70.
DR InterPro; IPR005024; Snf7_fam.
DR PANTHER; PTHR10766:SF14; TRANSMEMBRANE 9 SUPERFAMILY MEMBER 1; 1.
DR PANTHER; PTHR10766; TRANSMEMBRANE 9 SUPERFAMILY PROTEIN; 1.
DR Pfam; PF02990; EMP70; 1.
DR Pfam; PF03357; Snf7; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363079};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363079};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363079}.
FT TRANSMEM 446..468
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363079"
FT TRANSMEM 516..543
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363079"
FT TRANSMEM 549..570
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363079"
FT TRANSMEM 582..604
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363079"
FT TRANSMEM 616..643
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363079"
FT TRANSMEM 674..696
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363079"
FT TRANSMEM 708..732
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363079"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 85554 MW; 836E6BCB2A3AD84D CRC64;
MSGLGRVGGG GGRKKEKGPT PEEAIQKLKE TEKILIKKQE FLEQKIEQEL QTAKKHGTKN
KRAALQALRR KKRLEQQLAQ TDGTLSTLEF QREAIENATT NAEVLRTMEL AAQGLKKAYQ
DMDIDKVDEL MADITEQQEV AQQISDAISR PVGFGDDVDE DELLEELEEL EQEELARELL
HVGDEEEEPP VALPSVPATH PPAEPGSAAL RMTVLGHPRS WSCRWWPLLL LLLLTGREPG
VEAVTHYKAG DPVILYVNKV GPYHNPQETY HYYQLPVCCP EKIRHKSLSL GEVLDGDRMA
ESLYEIRFRE NVEKRVLCHM QLSSAQVEQL RQAIEELYYF EFVVDDLPIR GFVGYMEESG
FLPHSHKIGL WTHLDFHLEF HGDRIIFANV SVRDVKPHSL DGLRPDEFLG LTHTYSVRWS
ETSVERRSDR RRGDDGFFPR TLEIHWLSII NSMVLVFLLV GFVAVILMRV LRNDLARYNL
DEETTSAGSG DDFDQSDNGW KIIHTDVFRF PPYRGLLCAV LGVGAQFLAL GTGIIVMALL
GMFNVHRHGA INSAAILLYA LTCCISGYVS SHFYRQIGGE RWVWNIILTT SLFSVPFFLT
WSVVNSVHWA NGSTQALPAT TILLLLTVWL LVGFPLTVIG GIFGKNNASP FDAPCRTKNI
AREIPPQPWY KSTLVHMTVG GFLPFSAISV ELYYIFATVW GREQYTLYGI LFFVFAILLS
VGACISIALT YFQLSGEDHR WWWRSVLSVG STGLFIF
//
