ID W5QDB5_SHEEP Unreviewed; 565 AA.
AC W5QDB5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Translation initiation factor eIF2B subunit delta {ECO:0000256|ARBA:ARBA00044147};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit delta {ECO:0000256|ARBA:ARBA00044356};
GN Name=EIF2B4 {ECO:0000313|Ensembl:ENSOARP00000020713.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000020713.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000020713.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000020713.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000020713.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; AMGL01075875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01075876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000020713; -.
DR PaxDb; 9940-ENSOARP00000020713; -.
DR Ensembl; ENSOART00000020998.1; ENSOARP00000020713.1; ENSOARG00000019282.1.
DR eggNOG; KOG1467; Eukaryota.
DR HOGENOM; CLU_016218_3_3_1; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000019282; Expressed in mesenteric lymph node and 52 other cell types or tissues.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR10233; TRANSLATION INITIATION FACTOR EIF-2B; 1.
DR PANTHER; PTHR10233:SF14; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA; 1.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 61786 MW; 932D1C2544F341B9 CRC64;
MALIATRSPG RGPHXXXXXX XXXXXXXXRG APGGRSLERR VMATVAVAVR EDSGSGMKAE
LAPRPGAGGR EMTQEEKLQL RKEKKQQKKK RKEEKGAEAE TGSAVSAAQC QVGPAKHLAG
PDSQLGTAKE KVPAGRSKAE LRAERRAKQE AERALKQARK GDQGGPPPQA CPSTAGETPS
GVKRLPEHSQ VDDPTLLRRL VKKPERQQVP TRKDYGSKVS LFSHLPQYSR QNSLTQFMSI
PSSVIHPAMV RLGLQYSQGL VSGSNARCIA LLRALQQVIQ DYTTPPSEEL SRDLVNKLKP
YFSFLTQCRP LSASMYNAIK FLNKEITGVS SSKREEEAKS ELRAAIDRYI KEKIVLAAQA
ISRFAYKKIS NGDVILVYGC SSLVSQILQE AWAEGRQFRV VVVDSRPRLE GKHTLRSLVR
AGVPASYLLI PAASYVLPEV SKVLLGAHAL LANGSVMSRV GTAQLALVAR AHNVPVLVCC
ETYKFCERVQ TDAFVSNELD DPDDLLCERG EHVALANWQN HSSLRLLNLV YDVTPPELVD
LVITELGMIP CSSVPVVLRV KSSDQ
//
