ID W5QDI3_SHEEP Unreviewed; 379 AA.
AC W5QDI3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN Name=NEU2 {ECO:0000313|Ensembl:ENSOARP00000020781.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000020781.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000020781.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000020781.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000020781.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC (2->8)- glycosidic linkages of terminal sialic acid residues in
CC oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC synthetic substrates.; EC=3.2.1.18;
CC Evidence={ECO:0000256|ARBA:ARBA00000427};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC {ECO:0000256|ARBA:ARBA00009348}.
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DR EMBL; AMGL01000688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004003515.1; XM_004003466.3.
DR AlphaFoldDB; W5QDI3; -.
DR SMR; W5QDI3; -.
DR STRING; 9940.ENSOARP00000020781; -.
DR PaxDb; 9940-ENSOARP00000020781; -.
DR Ensembl; ENSOART00000021067.1; ENSOARP00000020781.1; ENSOARG00000019344.1.
DR eggNOG; ENOG502QSFT; Eukaryota.
DR HOGENOM; CLU_024620_2_1_1; -.
DR OMA; SDHGTTW; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000019344; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF6; SIALIDASE-2; 1.
DR Pfam; PF13088; BNR_2; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 3: Inferred from homology;
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 33..342
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13088"
SQ SEQUENCE 379 AA; 42255 MW; 4B91BD9BEEE253DB CRC64;
MASCPVLQRE RVFQSGARVY RIPALLYLPQ QKTLLAFAEE RTSKKDEHAK LIVLRRGSYD
TSTHQVQWHS QEAVSQAQLE GHRSMNPSPL YDEATGTIFL FFIAIPGQVS EHHQLQTRVN
ATRLCQVTSP DHGRSWSPPT DLTDSVIASA DKDWATFAVG PGHCLQLSNP TRSLVVPAYA
YRSHCCLKAP SPSAFCLVSH DHGRTWARGS FVDQDTLECQ VAEVRDGQQR VVYLNARSPH
QARVQAQSAN NGLDFKETQW VQKLVEPPHG CQGSIVSFPS PNVGSEPPDW WLLYTHPTDP
RQRSNLGVYL NRWSPGPATW SEPTLLAPGS CAYSDLQSMG TGPDGSPLFG CLYESDDYME
IVFVMFTLQQ AFPAEFLLQ
//
