ID W5QEC2_SHEEP Unreviewed; 1012 AA.
AC W5QEC2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN Name=ALK {ECO:0000313|Ensembl:ENSOARP00000021070.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000021070.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000021070.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000021070.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000021070.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|RuleBase:RU000312};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC {ECO:0000256|RuleBase:RU000312}.
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DR EMBL; AMGL01075930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01075931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01075932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01075933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01075934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QEC2; -.
DR SMR; W5QEC2; -.
DR STRING; 9940.ENSOARP00000021070; -.
DR PaxDb; 9940-ENSOARP00000021070; -.
DR Ensembl; ENSOART00000021364.1; ENSOARP00000021070.1; ENSOARG00000019617.1.
DR eggNOG; KOG1095; Eukaryota.
DR HOGENOM; CLU_001878_2_2_1; -.
DR OMA; NTACERQ; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000019617; Expressed in gastric lymph node and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd06263; MAM; 1.
DR CDD; cd05036; PTKc_ALK_LTK; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24416:SF276; ALK TYROSINE KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF12810; Gly_rich; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kinase {ECO:0000256|ARBA:ARBA00023137}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW Receptor {ECO:0000256|RuleBase:RU000312};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|RuleBase:RU000312, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 610..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..212
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 691..967
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 983..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 725
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1012 AA; 110206 MW; 05F369F82EA68B24 CRC64;
CAPGSSPGSK MALQSSFTCW NGTVLQLGQA CDFHRDCAQG EDEGQLCRKL PDGFYCDFED
GFCGWTQTSP SPHTPQWQVQ TLKDAQFQDH QGHALLLSIT DAPTSENATV TSATFPAPMK
NSPCELRMSW LIRGVLQGNV SLMLVENKTG KEQSRMIWRV ATLEGLSLWQ RTVLPLLEVA
DRFWLQIVAW WRQGSRAVVA FDNISVSLDC YLTISREDKI PQNTAPKSRN LFERNLNSEL
KPWVNPSKET PIFDPTVHWL FTTCGASGPH GPTQAQCNNA YRNSNLSVVV GSEGPLKGIQ
TWKVPATDTY SISGYGAAGG KGGKNTMMRS HGVSVLGIFN LEKDDTLYIL VGQQGEDACP
SANRLIQKVC IGENNVIEEE IRVNKSVHEW AGGGGGGGGA TYVFKMKDGV PVPLIIAAGG
GGRAYGAKTD TFHPERLENN SSVLGLNGNS GAAGGGGGWS DNTSLLWSGK SLLEGATGGH
SCPQAMKKWG WETRGGGGGG GGCSSGGGGG GYIGGNAASN NDPEMDGEDG VSFINPLGIL
YTPALKVMEG HGEVNIKHYL NCSHCEVDEC HMDPESHKII CFCDHGTVLA EDGVSCIVSP
TPEPHLPLSL ILSVVTSALV AALVLAFSGI MIVYRRKHQE LQAMQMELQS PEYKLSKLRT
STIMTDYNPN YCFAGKTSSI SDLKEVPRKS ITLIRGLGHG AFGEVYEGQV SGMPNDPSPL
QVAVKTLPEV CSEQDELDFL MEALIISKFN HQNIVRCIGV SLQALPRFIL LELMAGGDLK
SFLRETRPRP NQPSSLVMLD LLHVARDIAC GCQYLEENHF IHRDIAARNC LLTCPGPGRV
AKIGDFGMAR DIYRASYYRK GGCAMLPVKW MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL
GYMPYPSKSN QEVLEFVTSG GRMDPPKNCP GPVYRIMTQC WQHQPEDRPN FAIILERIEY
CTQDPDVINT ALPVEYGPLV EEEEKVPMRP QDPEGIPPLL VSGAQAKREE GR
//
