ID W5QGF1_SHEEP Unreviewed; 588 AA.
AC W5QGF1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Potassium voltage-gated channel subfamily Q member 4 {ECO:0008006|Google:ProtNLM};
GN Name=KCNQ4 {ECO:0000313|Ensembl:ENSOARP00000021800.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000021800.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000021800.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000021800.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000021800.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMGL01000966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01000967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01000968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QGF1; -.
DR SMR; W5QGF1; -.
DR STRING; 9940.ENSOARP00000021800; -.
DR PaxDb; 9940-ENSOARP00000021800; -.
DR Ensembl; ENSOART00000022104.1; ENSOARP00000021800.1; ENSOARG00000020299.1.
DR eggNOG; KOG1419; Eukaryota.
DR HOGENOM; CLU_011722_8_3_1; -.
DR OMA; YATCLHM; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000020299; Expressed in cerebellum and 45 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF7; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..588
FT /note="Potassium voltage-gated channel subfamily Q member
FT 4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004871482"
FT TRANSMEM 29..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..225
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 357..539
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 335..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 65511 MW; 1D54C49728D7D629 CRC64;
CRFLLVFSCL VLSVLSTIQE HQELANECLL ILEFVMIVVF GLEYIIRVWS AGCCCRYRGW
QGRFRFARKP FCVIDFIVFV ASVAVIAAGT QGNICATSAL RSMRFLQILR MVRMDRRGGT
WKLLGSVVYV PPQELITAWY IGFLVLIFAS FLVYLAEKDA NSDFSSYADS LWWGTITLTT
IGYGDKTPHT WLGRVLAAGF ALLGISFFAL PAGILGSGFA LKVQEQHRQK HFEKRRMPAA
NLIQAAWRLY STDASRAYLT ATWYYYDSIL PSFREEAVLR TQGQALVGGG ARALPRVPDG
APSRYPPVAT CHRPGSASFC PGESSRMGIK DRIRMGSSQR RTGPSKQHLA PPPTPTSPSS
EQVGEASSPT KVQKSWSFND RTRFRASLRL KPRTSAEEGP SEEMVEEKSY QCELTVDDVM
PAVKTVIRSV RILKFLVAKR KFKETLRPYD VKDVIEQYSA GHLDMLGRIK SLQARVDQIV
GRGPGDRKAR EKGDKGPSDT EVVDEISIMG RVVKVEKQVQ SIEHKLDLLL GFYSRCLRSG
TSASLGTAQV PLFDPDITSD YHSPVDHEDI SVSAQTLSIS RSVSTNMD
//
