ID W5QGQ3_SHEEP Unreviewed; 147 AA.
AC W5QGQ3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=lysozyme {ECO:0000256|ARBA:ARBA00012732};
DE EC=3.2.1.17 {ECO:0000256|ARBA:ARBA00012732};
GN Name=LOC443320 {ECO:0000313|Ensembl:ENSOARP00000021902.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000021902.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000021902.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000021902.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000021902.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Lysozymes have primarily a bacteriolytic function; those in
CC tissues and body fluids are associated with the monocyte-macrophage
CC system and enhance the activity of immunoagents.
CC {ECO:0000256|ARBA:ARBA00002647}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC between N-acetyl-D-glucosamine residues in chitodextrins.;
CC EC=3.2.1.17; Evidence={ECO:0000256|ARBA:ARBA00000632};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
CC {ECO:0000256|RuleBase:RU004440}.
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DR EMBL; AMGL01081006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QGQ3; -.
DR Ensembl; ENSOART00000022207.1; ENSOARP00000021902.1; ENSOARG00000020393.1.
DR OMA; GLSPWYG; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000020393; Expressed in abomasum and 53 other cell types or tissues.
DR ExpressionAtlas; W5QGQ3; baseline.
DR GO; GO:0003796; F:lysozyme activity; IEA:UniProtKB-EC.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR CDD; cd16897; LYZ_C; 1.
DR Gene3D; 1.10.530.10; -; 1.
DR InterPro; IPR001916; Glyco_hydro_22.
DR InterPro; IPR019799; Glyco_hydro_22_CS.
DR InterPro; IPR000974; Glyco_hydro_22_lys.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR PANTHER; PTHR11407; LYSOZYME C; 1.
DR PANTHER; PTHR11407:SF28; LYSOZYME C; 1.
DR Pfam; PF00062; Lys; 1.
DR PRINTS; PR00137; LYSOZYME.
DR PRINTS; PR00135; LYZLACT.
DR SMART; SM00263; LYZ1; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
DR PROSITE; PS00128; GLYCOSYL_HYDROL_F22_1; 1.
DR PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2; 1.
PE 3: Inferred from homology;
KW Antimicrobial {ECO:0000256|ARBA:ARBA00022529};
KW Bacteriolytic enzyme {ECO:0000256|ARBA:ARBA00022638};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..147
FT /note="lysozyme"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004870323"
FT DOMAIN 95..113
FT /note="Glycosyl hydrolases family 22 (GH22)"
FT /evidence="ECO:0000259|PROSITE:PS00128"
SQ SEQUENCE 147 AA; 16181 MW; BF31A2BC54DC782F CRC64;
MKALVILGLL CLSVAVQGKV FERCELARTL KELGLDGYKG VSLANWLCLT KWESSYNTKA
TNYNPGSEST DYGIFQINSK WWCNDGKTPN AVDGCHVSCS ELMENNIAKA VACAKHIVSE
QGITAWVAWK SHCRDHDVSS YVEGCSL
//