ID W5QH64_SHEEP Unreviewed; 211 AA.
AC W5QH64;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Synaptosomal-associated protein {ECO:0000256|RuleBase:RU003496};
GN Name=SNAP23 {ECO:0000313|Ensembl:ENSOARP00000022064.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022064.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000022064.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022064.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000022064.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004193};
CC Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
CC -!- SIMILARITY: Belongs to the SNAP-25 family.
CC {ECO:0000256|ARBA:ARBA00009480, ECO:0000256|RuleBase:RU003496}.
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DR EMBL; AMGL01102743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004010530.1; XM_004010481.3.
DR AlphaFoldDB; W5QH64; -.
DR SMR; W5QH64; -.
DR STRING; 9940.ENSOARP00000022064; -.
DR PaxDb; 9940-ENSOARP00000022064; -.
DR Ensembl; ENSOART00000022369.1; ENSOARP00000022064.1; ENSOARG00000020535.1.
DR GeneID; 101117588; -.
DR KEGG; oas:101117588; -.
DR CTD; 8773; -.
DR eggNOG; KOG3065; Eukaryota.
DR HOGENOM; CLU_096939_0_0_1; -.
DR OMA; ITRTHHQ; -.
DR OrthoDB; 388796at2759; -.
DR Proteomes; UP000002356; Chromosome 7.
DR Bgee; ENSOARG00000020535; Expressed in skeletal muscle tissue of biceps brachii and 54 other cell types or tissues.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR CDD; cd15895; SNARE_SNAP23N; 1.
DR CDD; cd15885; SNARE_SNAP25C; 1.
DR Gene3D; 1.20.5.110; -; 2.
DR InterPro; IPR000928; SNAP-25_dom.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19305; SYNAPTOSOMAL ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR19305:SF4; SYNAPTOSOMAL-ASSOCIATED PROTEIN 23; 1.
DR Pfam; PF00835; SNAP-25; 1.
DR SMART; SM00397; t_SNARE; 2.
DR SUPFAM; SSF58038; SNARE fusion complex; 2.
DR PROSITE; PS50192; T_SNARE; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 14..76
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
FT DOMAIN 146..208
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
FT REGION 102..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 45..79
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 170..204
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 106..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 211 AA; 23226 MW; ABFB95BDC9651BCB CRC64;
MDNLSAEEIQ LRANQVTDES LESTRRILGL AIESQDAGIK TITMLDEQGE QLKRIEEGMD
QINKDMREAE KTLTELNKCC GLCVCPCSRT KNFESSKAYK ATWGDGGDNS PSNIVSKQPG
RVTNGQPQQA TAGAASGGYI KRITNDARED EMEENLTQVG SILGNLKNMA LDMGNEIEAQ
NRQIDRITEK ADTNKDRIDN ANARAKKLID S
//
