ID W5QHP8_SHEEP Unreviewed; 623 AA.
AC W5QHP8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=FERM domain-containing protein {ECO:0000259|PROSITE:PS50057};
GN Name=FRMD6 {ECO:0000313|Ensembl:ENSOARP00000022248.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022248.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000022248.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022248.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000022248.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01103012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01103013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01103014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01103015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01103016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01103017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01103018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QHP8; -.
DR SMR; W5QHP8; -.
DR STRING; 9940.ENSOARP00000022248; -.
DR PaxDb; 9940-ENSOARP00000022248; -.
DR Ensembl; ENSOART00000022553.1; ENSOARP00000022248.1; ENSOARG00000020699.1.
DR eggNOG; KOG4371; Eukaryota.
DR HOGENOM; CLU_036910_1_1_1; -.
DR OMA; QPILRHI; -.
DR Proteomes; UP000002356; Chromosome 7.
DR Bgee; ENSOARG00000020699; Expressed in aortic valve and 53 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13185; FERM_C_FRMD1_FRMD6; 1.
DR CDD; cd17198; FERM_F1_FRMD6; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR041781; FRMD6-FERM_C.
DR InterPro; IPR047145; FRMD6-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13429; FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY; 1.
DR PANTHER; PTHR13429:SF11; FERM DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 16..328
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 364..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 71924 MW; EB8A723D08F41E4D CRC64;
MNKLNFHNNR VMQDRRSVCI FLPNDESLNI IINVKILCHQ LLVQVCDLLR LKDCHLFGLS
VIQNNEHVYM ELSQKLYKYC PKEWKKEASK VRQYEVTWGI DQFGPPMIIH FRVQYYVENG
RLISDRAARY YYYWHLRKQV LHSQCVLREE AYFLLAAFAL QADLGNFKRN KHYGKYFEPE
AYFPSWVVSK RGKDYILKHI PNMHKDQFAL TASEAHLKYI KEAVRLDDVA VHYYRLYKDK
REIEASLTLG LTMRGIQIFQ NLDEEKQLLY DFPWTNVGKL VFVGKKFEIL PDGLPSARKL
IYYTGCPMRS RHLLQLLSNS HRLYMNLQPV LRHIRKLEEN EEKKQYRESY ISDNLDLDMD
QLEKRSRASG SSAGSMKHKR LSRHSTASHS SSHTSGIEAD TKARDAGPED AYPGSAIHRK
LKTCSSMTSH GSSHTSGGVE SGGKDRLEED SQDDEIEMLV DDPRDLEQMN EESLEVSPDM
CIYITEDMLL SRKLNGHSGL IVKEIGSSTS SSSETVVKLR GQSTDSLPQT ICRKPKTSTD
RHSLSLDDIR LYQKDFLRIA GLCQDTAQSY TFGCGHELDE EGLYCSSCLA QQCVNIQDAF
PVKRTSKYFS LDLTHDEVPE FVV
//
