ID W5QHV8_SHEEP Unreviewed; 1151 AA.
AC W5QHV8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Phospholipase {ECO:0000256|PIRNR:PIRNR009376};
DE EC=3.1.4.4 {ECO:0000256|PIRNR:PIRNR009376};
GN Name=PLD1 {ECO:0000313|Ensembl:ENSOARP00000022308.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022308.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000022308.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022308.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000022308.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445,
CC ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4;
CC Evidence={ECO:0000256|PIRNR:PIRNR009376};
CC -!- SIMILARITY: Belongs to the phospholipase D family.
CC {ECO:0000256|ARBA:ARBA00008664, ECO:0000256|PIRNR:PIRNR009376}.
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DR EMBL; AMGL01009823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QHV8; -.
DR SMR; W5QHV8; -.
DR STRING; 9940.ENSOARP00000022308; -.
DR PaxDb; 9940-ENSOARP00000022308; -.
DR Ensembl; ENSOART00000022613.1; ENSOARP00000022308.1; ENSOARG00000020756.1.
DR eggNOG; KOG1329; Eukaryota.
DR HOGENOM; CLU_000690_2_0_1; -.
DR OMA; EPQNYIS; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000020756; Expressed in rumen and 56 other cell types or tissues.
DR ExpressionAtlas; W5QHV8; baseline.
DR GO; GO:0070290; F:N-acylphosphatidylethanolamine-specific phospholipase D activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006654; P:phosphatidic acid biosynthetic process; IEA:InterPro.
DR CDD; cd01254; PH_PLD; 1.
DR CDD; cd09842; PLDc_vPLD1_1; 1.
DR CDD; cd09844; PLDc_vPLD1_2; 1.
DR CDD; cd07296; PX_PLD1; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 3.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR InterPro; IPR016555; PLipase_D_euk.
DR InterPro; IPR015679; PLipase_D_fam.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR18896:SF57; PHOSPHOLIPASE D1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00614; PLDc; 1.
DR Pfam; PF13091; PLDc_2; 1.
DR Pfam; PF00787; PX; 1.
DR PIRSF; PIRSF009376; Phospholipase_D_euk; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00155; PLDc; 2.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 3.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50035; PLD; 2.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR009376};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR009376};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR009376};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 195..327
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 574..601
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 968..995
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..652
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1151 AA; 132792 MW; 55AE495EA0900006 CRC64;
MRLNYETLGE KSQKHGPAKR FRGRRPPTRR GRPACAETCL ARHRLAPPLL GQRESRRGVP
GDGAVPTLAR PLSLLPCLQR CQLRGSPENP PPPRRFLRPP SRHSPFAFTL SQANMSLKNE
PRVNTSALQK IAADMSNLIE NLDTRELHFE GEEVDYDVSP SDPRIQEVYI PFSAVYKTQG
FKEPNIQTYL SGCPIKVQVL EVERFTSTKR VPSINLYTIE LTHGEFKWQV KRKFKHFQEF
HRELLKYKAF IRIPIPTRRH TFRRQNVKEE PREMPALPRT SENMIRQEEQ FFSRRKQLED
YLTKLLKMPM YRNYHATTEF LDISQLSFIH DLGPKGIEGM IMKRSGGHRI PGLNCCGQGR
ACYRWAKRWL IVKDSFLLYM KPDSGAIAFV LLVDKEFRVK VGRKETETKY GLRIDNLSRT
LILKCNSYRH ARWWGGAIEE FIQKYGPDFL KDHRFGSYAA IQENTLAKWY VNAKGYFEDV
ANAMEEAKEE IFITDWWLSP EIFLKRPVVE GNRWRLDCIL KRKAQQGVRI FVMLYKEVEL
ALGINSEYSK RTLMRLHPNI KVMRHPDHVS SSVYLWAHHE KLVIIDQSVA FVGGIDLAYG
RWDDNEHRLT DVGSVKRVIG GPSLGSLTAE TTESMESLRL KDKNESDKDL PILNPPDDAN
SKLKGIGKPR KFSKFSLYRQ LHRHHLHDTD SISSIDSASN TASLRSVQTR VGELHGETRF
WHGKDYCNFV FKDWVQLDKP FADFIDRYST PRMPWHDIAS AVHGKAARDV ARHFIQRWNF
TKIMKPKYRS LSYPFLLPKS QTTAHELKYQ VPGSVHANVQ LLRSAADWSA GIKYHEESIH
AAYVYVIENS KHYIYIENQF FISCSDDRVV FNKIGDAIAQ RILKAHRESQ RYRVYVVIPL
LPGFEGDIST GGGNALQAIM HFNYRTMCRG ENSILGQLKA EIGNQWINYI SFCGLRTHAE
LEGNLVTELI YVHSKLLIAD DNTVIIGSAN INDRSMLGKR DSEMAVIVQD TETVPSVMDG
REYQAGRFAQ GLRLQCFRVV LGYLSGPSED IQDPVSDKFF KEVWVSTAAR NATIYDKVFR
CLPNDEVHNL IQLRDFISKP VLAKEDPIRA EEELKKIRGF LVQFPFYFLS EENLLPSVGT
KEAMVPMEVW T
//
