ID W5QHW4_SHEEP Unreviewed; 1297 AA.
AC W5QHW4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=TNIK {ECO:0000313|Ensembl:ENSOARP00000022314.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022314.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000022314.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022314.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000022314.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. STE20 subfamily.
CC {ECO:0000256|ARBA:ARBA00008874}.
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DR EMBL; AMGL01009833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01009840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOART00000022619.1; ENSOARP00000022314.1; ENSOARG00000020761.1.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000020761; Expressed in gastric lymph node and 55 other cell types or tissues.
DR ExpressionAtlas; W5QHW4; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR47096:SF1; CNH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47096; MISSHAPEN LIKE KINASE 1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 1..234
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 984..1271
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 229..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..281
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..735
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..768
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..787
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1297 AA; 148061 MW; CA7F6FDFA3A6E119 CRC64;
MDVTGDEEEE IKQEINMLKK YSHHRNIATY YGAFIKKNPP GMDDQLWLVM EFCGAGSVTD
LIKNTKGNTL KEEWIAYICR EILRGLSHLH QHKVIHRDIK GQNVLLTENA EVKLVDFGVS
AQLDRTVGRR NTFIGTPYWM APEVIACDEN PDATYDFKSD LWSLGITAIE MAEGAPPLCD
MHPMRALFLI PRNPAPRLKS KKWSKKFQSF IESCLVKNHS QRPATEQLMK HPFIRDQPNE
RQVRIQLKDH IDRTKKKRGE KDETEYEYSG SEEEEEENDS GEPSSILNLP GESTLRRDFL
RLQLANKERS EALRRQQLEQ QQRENEEHKR QLLAERQKRI EEQKEQRRRL EEQQRREKEL
RKQQEREQRR HYEEQMRREE ERRRAEHEQE YIRRQLEEEQ RQLEILQQQL LHEQALLLEY
KRKQLEEQRQ AERLQRQLKQ ERDYLVSLQH QRQEQRPVEK KPLYHYKEGM SPSEKPAWAK
EVEERSRLNR QSSPAMPHKV ANRISDPNLP PRSESFSISG VQPARTPPML RSVDPQIPHL
VAVKSQGPAL TASQSVHEQP TKGLSGFQEA LNVSSHRVEM PRQNSDPTSE NPPLPTRIEK
FDRSSWLRQE EDIPPKVPQR TTSISPALAR KNSPGNGSAL GPRLGSQPIR ASNPDLRRTE
PVLESSLQRT SSGSSSSSST PSSQPSSQGG SQPGSQAGSS ERTRVRANSK SEGSPVLPHE
PSKVKPEESR EITRPSRPAD LTALAKELRE LRIEETNRPL KKVTDYSSSS EESESSDEEE
EDGESETQDG TVAVSDIPRL IPTGAPGSAE QYNVGMVGTH GLETSHADTF GSSISREGTL
MIREPSGEKK RPGHSDSNGF AGHINLPDLV QQSHSPAGTP TEGLGRVSTH PQEMDAGTEY
GLGSSTKASF TPFVDPRVYQ TSPTDEDEED EESSAAALFT SELLRQEQAK LNEARKISVV
NVNPTNIRPH SDTPEIRKYK KRFNSEILCA ALWGVNLLVG TENGLMLLDR SGQGKVYNLI
NRRRFQQMDV LEGLNVLVTI SGKKNKLRVY YLSWLRNRIL HNDPEVEKKQ GWITVGDLEG
CIHYKVVKYE RIKFLVIALK NAVEIYAWAP KPYHKFMAFK SFADLQHKPL LVDLTVEEGQ
RLKVIFGSHT GFHVIDVDSG NSYDIYIPSH IQGNITPHAI VILPKTDGME MLVCYEDEGV
YVNTYGRITK DVVLQWGEMP TSVAYIHSNQ IMGWGEKAIE IRSVETGHLD GVFMHKRAQR
LKFLCERNDK VFFASVRSGG SSQVFFMTLN RNSMMNW
//
