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Database: UniProt
Entry: W5QIK3_SHEEP
LinkDB: W5QIK3_SHEEP
Original site: W5QIK3_SHEEP 
ID   W5QIK3_SHEEP            Unreviewed;      1089 AA.
AC   W5QIK3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   SubName: Full=Ubiquitin specific peptidase 8 {ECO:0000313|Ensembl:ENSOARP00000022555.1};
GN   Name=USP8 {ECO:0000313|Ensembl:ENSOARP00000022555.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022555.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022555.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022555.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022555.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; AMGL01103599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5QIK3; -.
DR   SMR; W5QIK3; -.
DR   STRING; 9940.ENSOARP00000022555; -.
DR   PaxDb; 9940-ENSOARP00000022555; -.
DR   Ensembl; ENSOART00000022866.1; ENSOARP00000022555.1; ENSOARG00000020988.1.
DR   eggNOG; KOG1868; Eukaryota.
DR   HOGENOM; CLU_009980_0_0_1; -.
DR   OMA; TCNKESA; -.
DR   Proteomes; UP000002356; Chromosome 7.
DR   Bgee; ENSOARG00000020988; Expressed in spleen and 55 other cell types or tissues.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   CDD; cd02674; Peptidase_C19R; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   InterPro; IPR015063; USP8_dimer.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR048498; WW_USP8.
DR   PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   PANTHER; PTHR21646:SF27; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8; 1.
DR   Pfam; PF00581; Rhodanese; 1.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF08969; USP8_dimer; 1.
DR   Pfam; PF20625; WW_USP8; 1.
DR   SMART; SM00450; RHOD; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR   SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT   DOMAIN          195..313
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000259|PROSITE:PS50206"
FT   DOMAIN          748..1080
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
FT   REGION          122..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          476..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          650..717
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..440
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        476..581
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        654..668
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        671..686
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1089 AA;  124521 MW;  FBE57C6AC88A2B94 CRC64;
     MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKNYVQSA LKIFKTAEES RLDRDEERAY
     VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPANIKKAIE EAERLSESLK LRYEEAEVRK
     KLEEKDRQEK EQLQKQKKQE AEREDDSTSD KSSLENVLDA KDKTQKINGE KSEKNETTEK
     GAITAKELYT MMMDKNISLI IMDARRMQDY LDSHISDSLS VPEEAISPGV TASWIEANLP
     DDSKDTWKKR GTVDYVVLLD WFSSAKDLQL GTTLRSLKDA LFKWESKAVL CNEPLVLEGG
     YENWLLCYPQ YTTNAKVTPP PRGKNEEVSV SWILVDFTYP SLEESVPSKP SAQMIPPIEI
     SENTELINSQ DERMGPLNIS APVEPIAASK SDVSPIIQPV PILKNIPQID RSKKPAIKLP
     EDHRMKSEST DHEEQSPQSE KVVPDRSTKP VFPPPTAMLT DEEKARIHAE TALLMEKNKQ
     EKELRERQQE EQKERLRREE QEQKDRKEQE AEENEVTEKQ QKAEQMEKKE SEQARKEDKE
     TSAKRGREIT GVKRQSKSEH ETTDAKKSVE DRGKRCPTPE VQKKSTGDVP HASVAGDSSS
     GKSREPLTRA RSEEMGRVVP GLPSGWAKFL DPITGTFRYY HSPTNTVHMY PPEMAPSSAP
     PSTPPTHKAK PQIPAERDRE PSKLKRSYSS PDITQAIQEE EKRRPTVTPA VNRENKPTSY
     PKAEITRLSA SQIRNLNPVF GGSGPALTGL RNLGNTCYMN SILQCLCNTP HLADYFNRNC
     YQDDINRSNL LGHKGEVAEE FGIIMKALWT GQYRYISPKD FKITIGKIND QFAGYSQQDS
     QELLLFLMDG LHEDLNKADN RKRHKEENND HLDDFKAAEH AWQKHKQLNE SIIVALFQGQ
     FKSTVQCLTC HKKSRTFEAF MYLSLPLAST SKCTLQDCLR LFSKEEKLTD NNRFYCSHCR
     ARRDSLKKIE IWKLPPVLLV HLKRFSYDGR WKQKLQTSVD FPLENLDLSQ YVIGPKNNLK
     KYNLFSVSNH YGGLDGGHYT AYCKNAARQR WFKFDDHEVS DISISSVKSS AAYILFYTSL
     GPRITDVAT
//
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