ID W5QIK3_SHEEP Unreviewed; 1089 AA.
AC W5QIK3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Ubiquitin specific peptidase 8 {ECO:0000313|Ensembl:ENSOARP00000022555.1};
GN Name=USP8 {ECO:0000313|Ensembl:ENSOARP00000022555.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022555.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000022555.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022555.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000022555.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AMGL01103599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5QIK3; -.
DR SMR; W5QIK3; -.
DR STRING; 9940.ENSOARP00000022555; -.
DR PaxDb; 9940-ENSOARP00000022555; -.
DR Ensembl; ENSOART00000022866.1; ENSOARP00000022555.1; ENSOARG00000020988.1.
DR eggNOG; KOG1868; Eukaryota.
DR HOGENOM; CLU_009980_0_0_1; -.
DR OMA; TCNKESA; -.
DR Proteomes; UP000002356; Chromosome 7.
DR Bgee; ENSOARG00000020988; Expressed in spleen and 55 other cell types or tissues.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR CDD; cd02674; Peptidase_C19R; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR015063; USP8_dimer.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR048498; WW_USP8.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF27; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF08969; USP8_dimer; 1.
DR Pfam; PF20625; WW_USP8; 1.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 195..313
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 748..1080
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 122..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..440
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..668
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..686
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1089 AA; 124521 MW; FBE57C6AC88A2B94 CRC64;
MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKNYVQSA LKIFKTAEES RLDRDEERAY
VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPANIKKAIE EAERLSESLK LRYEEAEVRK
KLEEKDRQEK EQLQKQKKQE AEREDDSTSD KSSLENVLDA KDKTQKINGE KSEKNETTEK
GAITAKELYT MMMDKNISLI IMDARRMQDY LDSHISDSLS VPEEAISPGV TASWIEANLP
DDSKDTWKKR GTVDYVVLLD WFSSAKDLQL GTTLRSLKDA LFKWESKAVL CNEPLVLEGG
YENWLLCYPQ YTTNAKVTPP PRGKNEEVSV SWILVDFTYP SLEESVPSKP SAQMIPPIEI
SENTELINSQ DERMGPLNIS APVEPIAASK SDVSPIIQPV PILKNIPQID RSKKPAIKLP
EDHRMKSEST DHEEQSPQSE KVVPDRSTKP VFPPPTAMLT DEEKARIHAE TALLMEKNKQ
EKELRERQQE EQKERLRREE QEQKDRKEQE AEENEVTEKQ QKAEQMEKKE SEQARKEDKE
TSAKRGREIT GVKRQSKSEH ETTDAKKSVE DRGKRCPTPE VQKKSTGDVP HASVAGDSSS
GKSREPLTRA RSEEMGRVVP GLPSGWAKFL DPITGTFRYY HSPTNTVHMY PPEMAPSSAP
PSTPPTHKAK PQIPAERDRE PSKLKRSYSS PDITQAIQEE EKRRPTVTPA VNRENKPTSY
PKAEITRLSA SQIRNLNPVF GGSGPALTGL RNLGNTCYMN SILQCLCNTP HLADYFNRNC
YQDDINRSNL LGHKGEVAEE FGIIMKALWT GQYRYISPKD FKITIGKIND QFAGYSQQDS
QELLLFLMDG LHEDLNKADN RKRHKEENND HLDDFKAAEH AWQKHKQLNE SIIVALFQGQ
FKSTVQCLTC HKKSRTFEAF MYLSLPLAST SKCTLQDCLR LFSKEEKLTD NNRFYCSHCR
ARRDSLKKIE IWKLPPVLLV HLKRFSYDGR WKQKLQTSVD FPLENLDLSQ YVIGPKNNLK
KYNLFSVSNH YGGLDGGHYT AYCKNAARQR WFKFDDHEVS DISISSVKSS AAYILFYTSL
GPRITDVAT
//