ID W5QIW7_SHEEP Unreviewed; 2890 AA.
AC W5QIW7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022669.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000022669.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022669.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000022669.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic granule
CC {ECO:0000256|ARBA:ARBA00004463}.
CC -!- SIMILARITY: Belongs to the S100-fused protein family.
CC {ECO:0000256|ARBA:ARBA00038258}.
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DR EMBL; AMGL01004679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01004680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01004681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01004682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01004683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; W5QIW7; -.
DR STRING; 9940.ENSOARP00000022669; -.
DR PaxDb; 9940-ENSOARP00000022669; -.
DR Ensembl; ENSOART00000022981.1; ENSOARP00000022669.1; ENSOARG00000021093.1.
DR eggNOG; ENOG502QQH0; Eukaryota.
DR HOGENOM; CLU_227793_0_0_1; -.
DR OMA; CKRRAVH; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000021093; Expressed in thymus and 6 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd00213; S-100; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003303; Filaggrin.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR PANTHER; PTHR22571:SF24; FILAGGRIN-2; 1.
DR PANTHER; PTHR22571; FILAGGRIN-RELATED; 1.
DR Pfam; PF03516; Filaggrin; 5.
DR Pfam; PF01023; S_100; 1.
DR PRINTS; PR00487; FILAGGRIN.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 49..84
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 96..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..2879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..708
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..752
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1019
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1094
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1228..1244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1269..1306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1307..1359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1403..1425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1440..1454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1455..1486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1526..1553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1554..1573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1574..1591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1600..1628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1629..1657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1681..1696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1708..1738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1747..1771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1772..1786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1811..1831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1832..1850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1851..1875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1876..1890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1891..1907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1915..1935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1936..1956
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1957..1979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1980..1994
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1995..2025
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2038..2081
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2090..2109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2132..2879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2890 AA; 301474 MW; FFC465F412A5343D CRC64;
MTNLLRSVVT VIDTFYKYTK QDGECGTLSK DELKELLEKE FRPILKNPDD PDTVDIIMHM
LDRDHDRRLD FTEFLLMVFK LAMACNKVLS KEYCKASGSK KRRRSHRHRE EESETEGEEE
DTSGQNSGYR YSEGEEHGYS SGGSRGTPKH RHGSGSRRLR RQGGLSSSEN QKGSEKRRHE
SSSGYSWSNG KERHGSSSGE LEGKRNKSHV SPSRVSGDEY KSGCGRWRGH GGRFGEQGNQ
SSYTQSGYQS GSSGEGHRCI SGGWASGYGQ HEPSSGSQST RQKGYGSRTC GQPQNCGGQQ
GKGSCQSSCC GQYGSGVSQS STYSQHGSGS CGYSSNSHQK RCSSNETSKC GQHRSSSGQY
SGFGQHGSGS GQYSGFGHCG CSSGQSSGFG HHESTSGQAC YGQHGSGSCQ YSGEGQYGSG
SAQSSGFGHQ KSISGQSTCG QHGSGSGQSS GFGQAGSSSG QSSGFEHHEC RSQQSGYGHH
ELGSGQSSGF GQHGSSSSQS SGFGQHRSGS CQSSSDSERH SEGSQRHSRS AQGQAGSQHG
ESGATVRGRH GTAHGHSEDT IRHGHSSQGH SAQTGSSQVG GRQFSHSEAS DSERHSEVSE
RHSGSTHGQA GSQHGESGAT VRGRHRTAHG ESGDTTRYGQ SSQGQSTRSG SSQTGRGASS
HSEASDSERH SEVSERHSGS THGQAGSPHG ESGATVRGRH RTAHGQSGDT TRHGHSSQGQ
STRSGSSQAG RRGSSHSEAS DSERHSEVSE RHSGSTHGQA GSQHGESGAT VRGRHRTAHG
QSEDTIRHGH SSQGHSAQTG SSQGQSTRSG SSQAGRRGSS HSEASDSERH SEVSERHSGS
THGQAGSQHG ESGATVRGRH GTAHGESGDT TRYGQSSQGQ STRSGSSQTG RRGSSHSEAS
DSERHSEVSE RHSGSTHGQA GSPHGESGAT VRGRQRTAHG QSGDTTRHGH SSQGQSTRSG
SSQTGRRGSS HSESGDTTRH GHSSQGQSTR SGSSQTGRRG SSHSEASDSE RHSEVSERHS
GSTHGQAGSQ HGESGATVRG RHRTAHGESG DTTRYGQSSQ GQSTRSGSSQ TGRRGSSHSE
ASDSERHSEV SERHSGSTHG QAGSPHGESG ATVRGRQRTA HGQSGDTTRH GHSSQGQSTR
SGSSQAGRRG SSHSEASDSE RHSEVSERHS GSTHGQAGSQ HGESGATVRG RQRTAHGQSG
DTTRIGHSSQ GQSTRSGSSQ TGRRGSSHSE ASDSERHSEV SERHSGSTHG QAGSQHGESG
ATVRGRHGTA HGESGDTTRY GQSRRRGSSH SEASDRERHS EVSERHSGST HGQAGSQHGE
SGATVRGSHR TVHGQSGDTS GHVHSGQGQS TWSNKQSSHT HAHFGKRHST SQISGRQRHR
SDQAWRHGSY GSAEYDYGQS GYGPSGGSRT SSRNSSPFRQ SKGKGSHESA SGKWKKISCT
HAGDNSTHSE SQQETHSESV NRRSRNTGQR QGSHHEQSRD SSRDSGTRHG QTSAESGNGR
HRESSVSQAS DSVGHARDSG RHSETTHGRP GSSSRNQHGS SHGQTGDSYR HSETNQGSHN
ERHARDSGRH SETTHGRPGS TTRNQHGSSH GHTGDSSRHS ESHQGQTSTG SRSSRHSESS
VSQASDNEGH ARDSGRHSET THGRSGSSSR KADSRNQHGF SHGQTGNSSR HSESHQGRHS
DSLQGRSGSS TGQRQGSHHE QSRDSSRQSG TRHGQTSTAS RSSRHSEPSV SQASDSEGHS
EDSGSRSVTT HGRSGSASRN QHGSVHGQTG DSSRHSESHQ GRHSDTVHQR SGSSTGQRQG
SHHEQSRDSS RQSGTGHGQT STGSRSSRHR ESSVSQASDS EGHSEDSGRQ SVTTHGRSGS
SSRNQHGSSH DQTGDSSRYS ESHQGRHSDS LQRRSGSSTG QRQGSHHEQS SDSSRHSGTQ
HGQTSTVSRS SRHRQSSVSK ASDSEGHSED SGRRSVTTHG RPGSASRNQH GSVHGQTGDS
SRHSESHQGR HSDTVHQRSQ QGQTSSGSGS SRHSESSVSQ ASDSEGHARD SGRHSETTHG
RSGSSSSNQH GSVHGQTGDS SRHSQFHQGS HGESIHQRIQ NHGAGQVWRH GSYGSSSYDY
GQLGTGSPEV HSPSHGLRGS HRKHVSSYDQ RRSGSRRPSS SIQHGSGSGQ SSGYGQHRSS
SGQSSGFSHH GTGIGQSSSY EQHSSTSRQS PNCSQHGPSL SHSTSCGQYG SGSGQSSSCS
QQSSGSSQSL NHGQHRSESS QTSSYGQQRT GSGQSSGCRQ HRSGSGESSG FNQHRTGLGQ
SSSYEQHGST SGQSQSCGQH RSSLGQSSSY GQHGSSQYSG HSQHRSGSCQ SSGHSQHGSG
SGQSSSCGQH GSRSRESSGF GQHGSGLGQS SSYGQHGSTS GQSSGYGQQG SNLGQSSSYG
QRGSSQYGSR QSYSHSQHRS GSRQSSGHSR HGSGSGQSSS YGQHGSTSGQ SSSCSQQGSN
LGQSSSYGQW GSSQYGSSQS SRNSRHRSGS SQSSSYGQQG SSQYGSGQSY SHSRHRSGSS
QSSGHSQHGS GSGQSSSCGQ HGSSSRESSG FGQHGSGLGQ SSSYGQHSST SGQSSGCGQQ
RSNLGQSSSY GQRGSSQYGS SQSYSHRRHR SGSSQSSGHS RHGSGSGQSS SCGQHGSSSR
QSSGFGQHGS GLGQSSSYGQ HGSTSGQSSS CSQQGSNLGQ SSSYGQRGSS QYGSSQSSGC
RQQGSGSGQS SSCGQHGSSS RQSSGFGQHG SGLGQSSSYG QHGSTSGQSS SCSQQGSNLG
HSSSYGQRGS SQYGSSQSSG CRQQGSGSGQ SSSCGQHGSS SRQSSGFGQH GCGLGQSSTY
GHHGSTSGQS SSCGQHISGS SRQQSQGCSQ GQTESGYSYS NCNEGQPGGS YRQELRSSTP
LYEYVQQQRC
//
