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Database: UniProt
Entry: W5QJ78_SHEEP
LinkDB: W5QJ78_SHEEP
Original site: W5QJ78_SHEEP 
ID   W5QJ78_SHEEP            Unreviewed;       744 AA.
AC   W5QJ78;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   31-JUL-2019, entry version 43.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000022780};
GN   Name=ADAM20 {ECO:0000313|Ensembl:ENSOARP00000022780};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000022780, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000022780, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000022780};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000022780}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AMGL01104397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9940.ENSOARP00000022780; -.
DR   Ensembl; ENSOART00000023095; ENSOARP00000022780; ENSOARG00000021194.
DR   GeneTree; ENSGT00940000161067; -.
DR   OMA; WAPPYCK; -.
DR   Proteomes; UP000002356; Chromosome 7.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00117091};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    744       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004871816.
FT   DOMAIN      204    395       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      403    489       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   DOMAIN      627    660       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REGION      663    701       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      719    744       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    678    692       Acidic. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    727    744       Acidic. {ECO:0000256|SAM:MobiDB-lite}.
FT   DISULFID    461    481       {ECO:0000256|PROSITE-ProRule:PRU00068}.
FT   DISULFID    650    659       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   744 AA;  83928 MW;  4E9878E6DF53D2B8 CRC64;
     MTVGEALVHF RVTPLLLWFG VCLFISGHCQ ARPSQHFSSP ELVIPLKVTG WGRNAKVPGW
     LSYSLRFGGQ RHITHMKVKK LLISRPLPVF TYTDQRSLHQ DQPYLPDDCY YHGYVEGVPK
     SLVALSTCSG GFRGVLQIND LAYEIEPVRS SATFEHWVYR IDSDDTQFPR KRCGLTEEEI
     ARQLELHNFT LKQSSYTGWW THLLFLELVV VVDNLRFVHS GSNVSVVQIE IATVVNVINS
     LYHPLEVDVT LTGLEIWTEG NQIATENMDT MLEDFAVWKF FNLDNRLPHD AAHLFIKKSF
     GIQLGLAYVD GVCQNPLNCA IIVFEDDSLF DTGLIVTHEL GHNLGMLHDT EFCVCEFEFC
     IMYPAKAVTS KFSNCSYGEF WNNVMRKGFC LISPPNPANI FRIEYCGNLV VEEGEECDCG
     TVQQCKRDHC CLPDCTLKPG AACAFGSCCK NCKVRSTGTL CRKQINACDL PEWCNGASHQ
     CPEDVYVQDG IPCSDSAYCY KKNCVNHDEQ CREIFGKDAR SASRSCYKEI NTQGNRFGHC
     GIRDIEYIKC EVPDILCGRV QCENVEVIPN LMEHSTVHQF QVNDTTCWGT DYHIGMSIPD
     VGQVKDGTMC GQKKICVHSR CVSMVPEPQA CQPKTCHMKG VCNSKQECHC NPGWAPPYCK
     DKGSGGSNSS GPPGNPQGDE EEEADEDDEA EQSEETKMVK NSHMLLWLIP LICLFKHKKE
     KPEMKTEEET EEEETEEEDM EEES
//
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