ID W5TAB2_9NOCA Unreviewed; 414 AA.
AC W5TAB2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 1 {ECO:0000313|EMBL:AHH16142.1};
DE EC=2.3.1.41 {ECO:0000313|EMBL:AHH16142.1};
GN Name=kasA2 {ECO:0000313|EMBL:AHH16142.1};
GN ORFNames=NONO_c13390 {ECO:0000313|EMBL:AHH16142.1};
OS Nocardia nova SH22a.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1415166 {ECO:0000313|EMBL:AHH16142.1, ECO:0000313|Proteomes:UP000019150};
RN [1] {ECO:0000313|EMBL:AHH16142.1, ECO:0000313|Proteomes:UP000019150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH22a {ECO:0000313|EMBL:AHH16142.1};
RX PubMed=24747905;
RA Luo Q., Hiessl S., Poehlein A., Daniel R., Steinbuchel A.;
RT "Insights into the Microbial Degradation of Rubber and Gutta-Percha by
RT Analysis of the Complete Genome of Nocardia nova SH22a.";
RL Appl. Environ. Microbiol. 80:3895-3907(2014).
CC -!- PATHWAY: Lipid metabolism; mycolic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004796}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; CP006850; AHH16142.1; -; Genomic_DNA.
DR RefSeq; WP_025347663.1; NZ_CP006850.1.
DR AlphaFoldDB; W5TAB2; -.
DR STRING; 1415166.NONO_c13390; -.
DR KEGG; nno:NONO_c13390; -.
DR PATRIC; fig|1415166.3.peg.1360; -.
DR eggNOG; COG0304; Bacteria.
DR HOGENOM; CLU_000022_69_2_11; -.
DR OrthoDB; 9808669at2; -.
DR UniPathway; UPA00915; -.
DR Proteomes; UP000019150; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:AHH16142.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516};
KW Reference proteome {ECO:0000313|Proteomes:UP000019150};
KW Transferase {ECO:0000256|RuleBase:RU003694, ECO:0000313|EMBL:AHH16142.1}.
FT DOMAIN 9..413
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 414 AA; 42892 MW; 489C103DFF4DB80A CRC64;
MTVSSRTRYR DVVVTSLAAT TSIAGDVDST WKGLLNGESG IDVLDDGFID QFELPVRIGG
HLKVVPSSAL TRDETRRLSY VEQMALVLGR EVWRNAGAPE VDPERLAVSI GTGLGGAEAL
IDVKDKMANG GYRRVSPLAV QMIMPNGAAA VVGLELGAKA GISTPVSACS SGSEAVANAW
KSIVMGDADV VVTGGVEGSI QAVPIAAFTM MRAMSTRNDD PKRASRPFDT DRDGFVFGEA
GAMMVLESEE HARARGATIH ARLLGAGVTS DGFHLVAPDP DGKGAARAIT RALQTAGLSK
TDVGHVNAHA TATPIGDTAE ARAIASAVGA HASVYAPKSA LGHSIGAVGA LESVLTVLSI
RDGVVPPTLN LENQDPDVDL DIVKGQARPG RIDYAVNNSF GFGGHNVSLS FGRY
//
