ID W5TAJ8_9NOCA Unreviewed; 1394 AA.
AC W5TAJ8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:AHH16227.1};
GN ORFNames=NONO_c14240 {ECO:0000313|EMBL:AHH16227.1};
OS Nocardia nova SH22a.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1415166 {ECO:0000313|EMBL:AHH16227.1, ECO:0000313|Proteomes:UP000019150};
RN [1] {ECO:0000313|EMBL:AHH16227.1, ECO:0000313|Proteomes:UP000019150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH22a {ECO:0000313|EMBL:AHH16227.1};
RX PubMed=24747905;
RA Luo Q., Hiessl S., Poehlein A., Daniel R., Steinbuchel A.;
RT "Insights into the Microbial Degradation of Rubber and Gutta-Percha by
RT Analysis of the Complete Genome of Nocardia nova SH22a.";
RL Appl. Environ. Microbiol. 80:3895-3907(2014).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP006850; AHH16227.1; -; Genomic_DNA.
DR STRING; 1415166.NONO_c14240; -.
DR KEGG; nno:NONO_c14240; -.
DR PATRIC; fig|1415166.3.peg.1449; -.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG3319; Bacteria.
DR HOGENOM; CLU_000022_2_13_11; -.
DR OrthoDB; 2472181at2; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000019150; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000019150}.
FT DOMAIN 1052..1127
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 221..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1394 AA; 147893 MW; 32980349EB91B49F CRC64;
MTRVGDDAAT PDIGGLPDFP LSEAQLRWWV AQQLYPDLPN TVAMYLDLRG PLQVGPLRAA
ALAAAAELQS PLVRFRIRAG GPRQFLDPDA FAPMAVVDLS GAADPAGAAR SRMAADHGAP
LDLLADRLTV ATLYRIGTDR HLLYLRSHHI ALDGVGAAAV LHRTAEIYSE TTGFGSIRPA
RRAPLSIAEL VADEAAYRDS DRARADAAYW REQLAGLPPS AGLSGTAAPP APHPHRVGGQ
LPEPTAERLV AVRERTGASF TELTIAAFAA YLAAMTHRDD LVVAVPMAVR PTAALRNSAG
SVSNVVPLRL SGFGEITVGE LIDRVRVRLI GALRHQRYRY EDMQRDRGEN RVARGGFGPV
VNVLGFVEPL RLGPLTGRAV LLALGPVEDL LINGYQLGAD DRTASIDIQA NPALYSRAAV
VWHHERFLLY FDEFLGAATD DRVAHLGSGA IVDAAPKGDL KGGSKPGSGR AAGTTPLPDA
RDRPSAPNSD DRSDVRGVRG IPVRPCDGTA SRTAPEGETA IGAARGAAAS HAAPGDAVDP
APHSVRLLPE LLRYAGHPDG VAVVDGERWW TCQAWNGWCA RWARELIEYG AGPGDSVVVA
VPRSAESVLA IGAVAATGAA FVPVDPSDPP ARLAAVVANS GARLGLTVAG MWDRLPDGPR
WLGLDDPDLL ARVSARPATP VSDADRVRPL RADHTAYVIH TSGTTGRPKA VAVTHRGLEA
LTDHISETYA VQAHSRVLHA HAPSFDAHLL ELLAASAAGA RLVIEPRTVV AGTELSDFLA
ANAITHFLTT PAVLATLRPQ SLPELRVVVV GGEVCPVDLA RRWCSAVRLF NGYGPTETTV
MAAQFEVPTR PVSAAVPIGP MLPGVRARVL DERLRPVPPG GIGELYVGGA GVAAGYRGDP
AATATCFVAD PEAPGRRCYR TGDRVRIDPA GVAEFLGRVD TQLSLRGRRI EPAEIESALT
ELPRIAQAVV AIDRAPQGER LIGYVVTDAE TSADEDDSIV FHDLIRRLRD RLPAAMVPAQ
LVRLPALPVT RHGKVDRAAL PPPPAVSHSF RAPETEAQRL VAASFATATG ADRVGVDDDF
FELGGNSLSG VAVAAEIANA TGQPVTVRWL YSASTVGELA DRLAAPVPDG DDGLGPVLML
RRNGIRAPLF CVHSAVPLAW CYAGLAAHIR DRPVIGLQSP LLDDAEPVET PGDIGDLADR
YIEQIRRIQP NGPYHLLGWS LGGQIAHAIA VRLCHLGAQV ETLVMLDSLV FTDELPPPPV
PRMRDLLTHL LGDEPDDADL LEDVTAEQAA VELSDAAPSF GTGLSAAQLT RLHRGYVDGV
RLSHRYRPGV FDGDLLYFSA TRGPTELFDA QLWRPYLTGA IVEHPVAATH AQLTNSDVVA
QIGPALAAHL RARR
//
