ID   W5TE51_9NOCA            Unreviewed;       362 AA.
AC   W5TE51;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:AHH17278.1};
DE            EC=1.1.1.85 {ECO:0000313|EMBL:AHH17278.1};
GN   Name=leuB1 {ECO:0000313|EMBL:AHH17278.1};
GN   ORFNames=NONO_c24830 {ECO:0000313|EMBL:AHH17278.1};
OS   Nocardia nova SH22a.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=1415166 {ECO:0000313|EMBL:AHH17278.1, ECO:0000313|Proteomes:UP000019150};
RN   [1] {ECO:0000313|EMBL:AHH17278.1, ECO:0000313|Proteomes:UP000019150}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SH22a {ECO:0000313|EMBL:AHH17278.1};
RX   PubMed=24747905;
RA   Luo Q., Hiessl S., Poehlein A., Daniel R., Steinbuchel A.;
RT   "Insights into the Microbial Degradation of Rubber and Gutta-Percha by
RT   Analysis of the Complete Genome of Nocardia nova SH22a.";
RL   Appl. Environ. Microbiol. 80:3895-3907(2014).
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; CP006850; AHH17278.1; -; Genomic_DNA.
DR   RefSeq; WP_038552834.1; NZ_CP006850.1.
DR   AlphaFoldDB; W5TE51; -.
DR   STRING; 1415166.NONO_c24830; -.
DR   KEGG; nno:NONO_c24830; -.
DR   PATRIC; fig|1415166.3.peg.2536; -.
DR   eggNOG; COG0473; Bacteria.
DR   HOGENOM; CLU_031953_0_1_11; -.
DR   OrthoDB; 5289857at2; -.
DR   Proteomes; UP000019150; Chromosome.
DR   GO; GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR   PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   PROSITE; PS00470; IDH_IMDH; 1.
PE   3: Inferred from homology;
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Oxidoreductase {ECO:0000313|EMBL:AHH17278.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019150}.
FT   DOMAIN          10..355
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   362 AA;  37783 MW;  0590FAFAE2020DD0 CRC64;
     MSAQARQTIR LGLIEGDGIG PEVVAATRAV VEEALSAAGA PAADWVRLPI GHAAIAECGD
     PLPETTLSAL DDLDAWIMGP HDNVSYAPEH RNGPPPGGAI RKRFGLYANI RPARAFPGVR
     AAAPDIDLII VRENSEGFYA DRNMFAGSGE FRPTPDVAMA VGVITRAACE RIARQACELA
     AARRGRLTIV HKANVLPMTM GMFRDVCAEV ARGYPGLEVG DEHVDAAAAH LVRAPADYDV
     VVTENLFGDI LSDLAGELSG SLGLAASLNC SADKAMAQAV HGAAPALAGH NRANPGALQL
     SAAMLLRWLG TRDDDAALRG AADRIERAVA ATLAAGIATA DLGGMASTGE FTEQVRARVH
     RR
//