ID W5TIB7_9NOCA Unreviewed; 414 AA.
AC W5TIB7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=3-oxoacyl-[acyl-carrier-protein] synthase {ECO:0000313|EMBL:AHH18743.1};
DE EC=2.3.1.41 {ECO:0000313|EMBL:AHH18743.1};
GN Name=kasA4 {ECO:0000313|EMBL:AHH18743.1};
GN ORFNames=NONO_c39590 {ECO:0000313|EMBL:AHH18743.1};
OS Nocardia nova SH22a.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1415166 {ECO:0000313|EMBL:AHH18743.1, ECO:0000313|Proteomes:UP000019150};
RN [1] {ECO:0000313|EMBL:AHH18743.1, ECO:0000313|Proteomes:UP000019150}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH22a {ECO:0000313|EMBL:AHH18743.1};
RX PubMed=24747905;
RA Luo Q., Hiessl S., Poehlein A., Daniel R., Steinbuchel A.;
RT "Insights into the Microbial Degradation of Rubber and Gutta-Percha by
RT Analysis of the Complete Genome of Nocardia nova SH22a.";
RL Appl. Environ. Microbiol. 80:3895-3907(2014).
CC -!- PATHWAY: Lipid metabolism; mycolic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004796}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; CP006850; AHH18743.1; -; Genomic_DNA.
DR RefSeq; WP_025350165.1; NZ_CP006850.1.
DR AlphaFoldDB; W5TIB7; -.
DR STRING; 1415166.NONO_c39590; -.
DR KEGG; nno:NONO_c39590; -.
DR PATRIC; fig|1415166.3.peg.4063; -.
DR eggNOG; COG0304; Bacteria.
DR HOGENOM; CLU_000022_69_2_11; -.
DR OrthoDB; 9808669at2; -.
DR UniPathway; UPA00915; -.
DR Proteomes; UP000019150; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:AHH18743.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516};
KW Reference proteome {ECO:0000313|Proteomes:UP000019150};
KW Transferase {ECO:0000256|RuleBase:RU003694, ECO:0000313|EMBL:AHH18743.1}.
FT DOMAIN 10..413
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 414 AA; 42771 MW; 05EEE0F6C0149186 CRC64;
MSVPTATQTP RDVVVTAMAA TTCLGPDLDS TWAALVAGKS GIGPLTDDFV TRYDLPVRIG
GRLVEQPSAH LTRIEQRRHS YVQQLALVLG RQVWQQAGAP ELDTERLGVA IGTGLGGGDA
FMTAVDAMRE GGYRKVPPLT VPMVMPNGPA ARVGLEFGAK AGVYAPTSAC SSGAEAIAHA
WRLIRSGEAD VVIAGGVEGY IEAVPIASFA MMRAMSTRND EPGLASRPFD RDRDGFVFGE
AGALLVLESE EFARARGAAV HGRILGAGIT SDGYHITGTE PEGAGAARAM RKAIAAAGLT
SADIDHIDAH ATSTPVGDAS EANAIAAVAK HASVYAPKSA LGHSIGAVGA LEAILTLCTL
RDQTVPPTLN FDNPDPGVDL DIVHGVARPQ RIAQALSNSF GFGGHNVTLA FGQA
//
