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Database: UniProt
Entry: W5U6R3_ICTPU
LinkDB: W5U6R3_ICTPU
Original site: W5U6R3_ICTPU 
ID   W5U6R3_ICTPU            Unreviewed;       756 AA.
AC   W5U6R3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   08-MAY-2019, entry version 26.
DE   SubName: Full=inhibitor of Nuclear factor kappa-B kinase subunit alpha {ECO:0000313|EMBL:AHH37671.1, ECO:0000313|RefSeq:XP_017320171.1};
GN   Name=chuk {ECO:0000313|EMBL:AHH37671.1,
GN   ECO:0000313|RefSeq:XP_017320171.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH37671.1};
RN   [1] {ECO:0000313|EMBL:AHH37671.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Mixed {ECO:0000313|EMBL:AHH37671.1};
RX   PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA   Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA   Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA   Peatman E., Liu Z.;
RT   "Efficient assembly and annotation of the transcriptome of catfish by
RT   RNA-Seq analysis of a doubled haploid homozygote.";
RL   BMC Genomics 13:595-595(2012).
RN   [2] {ECO:0000313|RefSeq:XP_017320171.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017320171.1};
RG   RefSeq;
RL   Submitted (NOV-2017) to UniProtKB.
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DR   EMBL; JT406644; AHH37671.1; -; mRNA.
DR   RefSeq; XP_017320171.1; XM_017464682.1.
DR   GeneID; 108263650; -.
DR   KEGG; ipu:108263650; -.
DR   CTD; 1147; -.
DR   KO; K04467; -.
DR   OrthoDB; 1013139at2759; -.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0008384; F:IkappaB kinase activity; IEA:InterPro.
DR   InterPro; IPR041185; IKBKB_SDD.
DR   InterPro; IPR022007; IKKbetaNEMObind.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF18397; IKBKB_SDD; 1.
DR   Pfam; PF12179; IKKbetaNEMObind; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM01239; IKKbetaNEMObind; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000221080};
KW   Kinase {ECO:0000313|EMBL:AHH37671.1,
KW   ECO:0000313|RefSeq:XP_017320171.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221080};
KW   Transferase {ECO:0000313|EMBL:AHH37671.1,
KW   ECO:0000313|RefSeq:XP_017320171.1}.
FT   DOMAIN       15    301       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   COILED      338    358       {ECO:0000256|SAM:Coils}.
FT   COILED      558    578       {ECO:0000256|SAM:Coils}.
FT   COILED      707    727       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   756 AA;  86848 MW;  88B9E2264A56B6C1 CRC64;
     MEKPPFKQTQ CCGAWAMKER LGTGGFGHVY LYQHQETSEK IAVKLCRLEL NARNKDRWSR
     EIQIMKKLNH LNVVTARDVP EEMEHIALND LPLLAMEYCS RGDLRKLLSK PENCCGLKES
     EVLSLLNDVG SGIQYLHANK IIHRDLKPEN IVLQEINGKL VHKIIDLGYA KDLDQGSLCT
     SFVGTLQYLA PELFESKPYT VTVDYWSFGT MIFECSCGFR PFLHNLQPVQ WTSKVRNKGP
     KDIMAVEDMN GEVRFSSHLP YPNNLSSTLL EPLECLLQLM LKWDPVQRGG IIHPDTKQPQ
     CFAQLDQILN MKVVHILNMT TTGVHSFRLS PEETLHSLQQ SIENMTKIEQ GNQELLQETG
     VMLDPRKPAA QCVLDGVRGW DSYIVYLFDK SLTKYTGPFT ARPLPESVNF IVRETKTQLP
     LNALKKVWGE AVSYICGLRE DYSRLFQGQR AAMLSLLRYN TNLTRYKNLM FSCSQQLKAK
     LDFFKSSIQY DLEKYSDQMQ YGISSEKMLK AWQENEEKAA AFGQVAEIGH LDEEIMALHS
     EIVELQRSPY ARRQGDVMEQ LEEKAIELYK QLKAKCKMND SQHGYSDSSE MVKVIVQTVQ
     NQDKVLKDLY AHLSKILQSK QKIIELFPKI EKTLENIKEA DGTVMQMQMK RQREFWHLLK
     IACAQNTTRS QSADVSSSLS VWPQHPQQPC SPRLPMSLPA PHDTETLNQL LEENQKYLSQ
     LTSLLQETAE EKSESIMDQD WSWTKYESLF AKLQPL
//
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