ID W5U8T9_ICTPU Unreviewed; 1100 AA.
AC W5U8T9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Zinc finger E-box-binding homeobox 1 {ECO:0000313|EMBL:AHH37984.1, ECO:0000313|RefSeq:XP_017338586.1};
GN Name=ZEB1 {ECO:0000313|EMBL:AHH37984.1};
GN Synonyms=zeb1b {ECO:0000313|RefSeq:XP_017338586.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH37984.1};
RN [1] {ECO:0000313|EMBL:AHH37984.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH37984.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017338586.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017338586.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JT407425; AHH37984.1; -; mRNA.
DR RefSeq; XP_017338586.1; XM_017483097.3.
DR STRING; 7998.ENSIPUP00000016624; -.
DR Ensembl; ENSIPUT00000017326; ENSIPUP00000016624; ENSIPUG00000011262.
DR GeneID; 108273701; -.
DR KEGG; ipu:108273701; -.
DR CTD; 114425; -.
DR OMA; ANYINFP; -.
DR OrthoDB; 4266655at2759; -.
DR Proteomes; UP000221080; Chromosome 13.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF11; ZINC FINGER E-BOX-BINDING HOMEOBOX 2; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR Pfam; PF05605; zf-Di19; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000313|EMBL:AHH37984.1};
KW Homeobox {ECO:0000313|EMBL:AHH37984.1, ECO:0000313|RefSeq:XP_017338586.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 134..162
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 164..191
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 206..233
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 234..268
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 834..861
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 862..889
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 890..918
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..978
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1028
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1100 AA; 120394 MW; 3663941563C42281 CRC64;
MADGPRCKRR KQANPKRTSV SNYSNVLEGQ SDSDDEDKLH IVEEDATPMD GADGESVAHD
DDANGPDDRW DEVKEECVSE EDERSRDALV EEMLQQGDTA VIFPEAPEDE PRQGTPETSG
HDENGTPDAF SQLLTCPYCS RGYKRYTSLK EHIKYRHEKS EDNFSCSLCS YTFSHRTQLD
RHMSAHKAGR DQRHVTQTGG GGNRKFKCTE CGKAFKYKHH LKEHLRIHSG EKPYECPNCK
KRFSHSGSYS SHISSKKCIG LISVNGRPRP SPTTGGTKTP QCPSPSLPSS PATARTQIRD
KLDHSKPLQE QLPITQIKSE PLDYEYKPVV VAPAAPGGVN GVFQGGAAAP LQGAVQAVVL
PTVGLVSPIS INLGDLQNML KVAVDGNVIR QVLENAQAKG QPANTGRVAI AQAPQQVIQA
ISLPIVDQDG TTKIIINYSL DPSQAQAALQ NLKKEPVGQN TDSCKAERLP EDLTVKSKTT
RDKTTITVDE EWQQEKGKLY NHTTDKHCVK EEQEVNGTHL EEKSEDADGL CPGQPPLKNL
MSLLKAYFAL NAEPTKEALA KISESVNLPT DIVRKWFEKM QNGQIPMEIS TATPQKEQSN
GIDINGTPEE TQKSVSEQDS KRNQEEEEEM ELRSPAEGTT AGISGAENGP TSPLPLNLSA
DGPVPAQTAE EGEGPLDLSL PKSVAAANTT SAHSVYSAQD EPLNLVCTKK EVLSNASTST
AIYASQTSAN PLNIVTTQLP TLVAITKQGP GQCLRTLTTT KQTILIPQLA YTYTTTASSP
AGGDTPQKAI LQVNGVKEEK QEAGSEAASV LEEQTDSDSG PVRKKMKKTD NGLYACDLCD
KIFQKSSSLL RHKYEHTGKR PHECGICSKA FKHKHHLIEH LRLHSGEKPY QCDKCGKRFS
HSGSYSQHMN HRYSYCKKEA HGQNLVQRDE EEENPNEEQA GAASTTASPP SQVDSDERGS
SAREDEESEE EDVMGSGSMV DEDEIQVVRI GEEGGEDEED TGEQYRMEEM DTGNEEAVRE
NGGHEEDTVE SQEEGEEDGE MMKVVVMQDD EGDEEEQTEI TEAMDMQENI GEEKAEDEGE
NVNEEGGNEG TTPSENGDVK
//
