ID W5U9B8_ICTPU Unreviewed; 326 AA.
AC W5U9B8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Target of rapamycin complex subunit lst8 {ECO:0000256|ARBA:ARBA00018867, ECO:0000256|RuleBase:RU369068};
DE Short=TORC subunit lst8 {ECO:0000256|RuleBase:RU369068};
GN Name=mlst8 {ECO:0000313|EMBL:AHH38405.1,
GN ECO:0000313|RefSeq:XP_017339603.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH38405.1};
RN [1] {ECO:0000313|EMBL:AHH38405.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH38405.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017339603.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017339603.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Subunit of TORC1 and TORC2, which regulate cell growth and
CC survival in response to nutrient and hormonal signals.
CC {ECO:0000256|RuleBase:RU369068}.
CC -!- SUBUNIT: Part of TORC1 complex. Part of the TORC2 complex.
CC {ECO:0000256|RuleBase:RU369068}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU369068}.
CC Lysosome membrane {ECO:0000256|ARBA:ARBA00004656}.
CC -!- SIMILARITY: Belongs to the WD repeat LST8 family.
CC {ECO:0000256|ARBA:ARBA00009890, ECO:0000256|RuleBase:RU369068}.
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DR EMBL; JT408614; AHH38405.1; -; mRNA.
DR RefSeq; XP_017339603.1; XM_017484114.3.
DR STRING; 7998.ENSIPUP00000003322; -.
DR Ensembl; ENSIPUT00000003491; ENSIPUP00000003322; ENSIPUG00000002358.
DR GeneID; 108274161; -.
DR KEGG; ipu:108274161; -.
DR CTD; 64223; -.
DR OMA; VQRNYKH; -.
DR OrthoDB; 650241at2759; -.
DR Proteomes; UP000221080; Chromosome 13.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031931; C:TORC1 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031932; C:TORC2 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031929; P:TOR signaling; IEA:UniProtKB-UniRule.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR037588; MLST8.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19842; G BETA-LIKE PROTEIN GBL; 1.
DR PANTHER; PTHR19842:SF0; TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|RuleBase:RU369068};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU369068};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 81..122
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 216..257
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 277..307
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 326 AA; 36228 MW; 799BBD6895960928 CRC64;
MNVNQGTVGS DPVILATAGY DHTVRFWQAH SGICTRTVQH QDSQVNSLEV TPDRSMIAAA
GYQHIRMYDL NSNNPNPVIN YDGVSKNITS VGFHEDGRWM YTGGEDCMAR IWDLRSRNLQ
CQRIFQVNAP INCVCLHPNQ AELFVGDQSG VIHVWDLKTD HNEQLIPEPE VSVNSVHIDP
DASYMAAVNS SGNCYVWNLA GGIGDEVTQL IPKTKIPAHK RYSLRCKFSP DSTLLATCSA
DQTCKIWRTS NFSLMTELSI KSNNPGETSR GWMWDCAFSG DSQYIVTASS DNLARLWCVE
TGEIKREYSG HQKAVVCLAF NDSVLG
//