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Database: UniProt
Entry: W5U9B8_ICTPU
LinkDB: W5U9B8_ICTPU
Original site: W5U9B8_ICTPU 
ID   W5U9B8_ICTPU            Unreviewed;       326 AA.
AC   W5U9B8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=Target of rapamycin complex subunit lst8 {ECO:0000256|ARBA:ARBA00018867, ECO:0000256|RuleBase:RU369068};
DE            Short=TORC subunit lst8 {ECO:0000256|RuleBase:RU369068};
GN   Name=mlst8 {ECO:0000313|EMBL:AHH38405.1,
GN   ECO:0000313|RefSeq:XP_017339603.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH38405.1};
RN   [1] {ECO:0000313|EMBL:AHH38405.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Mixed {ECO:0000313|EMBL:AHH38405.1};
RX   PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA   Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA   Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA   Peatman E., Liu Z.;
RT   "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT   Seq analysis of a doubled haploid homozygote.";
RL   BMC Genomics 13:595-595(2012).
RN   [2] {ECO:0000313|RefSeq:XP_017339603.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017339603.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Subunit of TORC1 and TORC2, which regulate cell growth and
CC       survival in response to nutrient and hormonal signals.
CC       {ECO:0000256|RuleBase:RU369068}.
CC   -!- SUBUNIT: Part of TORC1 complex. Part of the TORC2 complex.
CC       {ECO:0000256|RuleBase:RU369068}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU369068}.
CC       Lysosome membrane {ECO:0000256|ARBA:ARBA00004656}.
CC   -!- SIMILARITY: Belongs to the WD repeat LST8 family.
CC       {ECO:0000256|ARBA:ARBA00009890, ECO:0000256|RuleBase:RU369068}.
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DR   EMBL; JT408614; AHH38405.1; -; mRNA.
DR   RefSeq; XP_017339603.1; XM_017484114.3.
DR   STRING; 7998.ENSIPUP00000003322; -.
DR   Ensembl; ENSIPUT00000003491; ENSIPUP00000003322; ENSIPUG00000002358.
DR   GeneID; 108274161; -.
DR   KEGG; ipu:108274161; -.
DR   CTD; 64223; -.
DR   OMA; VQRNYKH; -.
DR   OrthoDB; 650241at2759; -.
DR   Proteomes; UP000221080; Chromosome 13.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031931; C:TORC1 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0031932; C:TORC2 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0031929; P:TOR signaling; IEA:UniProtKB-UniRule.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR037588; MLST8.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19842; G BETA-LIKE PROTEIN GBL; 1.
DR   PANTHER; PTHR19842:SF0; TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8; 1.
DR   Pfam; PF00400; WD40; 6.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|RuleBase:RU369068};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU369068};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          81..122
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          216..257
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          277..307
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   326 AA;  36228 MW;  799BBD6895960928 CRC64;
     MNVNQGTVGS DPVILATAGY DHTVRFWQAH SGICTRTVQH QDSQVNSLEV TPDRSMIAAA
     GYQHIRMYDL NSNNPNPVIN YDGVSKNITS VGFHEDGRWM YTGGEDCMAR IWDLRSRNLQ
     CQRIFQVNAP INCVCLHPNQ AELFVGDQSG VIHVWDLKTD HNEQLIPEPE VSVNSVHIDP
     DASYMAAVNS SGNCYVWNLA GGIGDEVTQL IPKTKIPAHK RYSLRCKFSP DSTLLATCSA
     DQTCKIWRTS NFSLMTELSI KSNNPGETSR GWMWDCAFSG DSQYIVTASS DNLARLWCVE
     TGEIKREYSG HQKAVVCLAF NDSVLG
//
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