ID W5UBU2_ICTPU Unreviewed; 790 AA.
AC W5UBU2;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Amyloid beta A4 protein-binding family A member 2 {ECO:0000313|EMBL:AHH39054.1};
DE SubName: Full=Amyloid-beta A4 precursor protein-binding family A member 2 isoform X1 {ECO:0000313|RefSeq:XP_017314194.1, ECO:0000313|RefSeq:XP_017314195.1};
GN Name=Apba2 {ECO:0000313|EMBL:AHH39054.1};
GN Synonyms=apba2b {ECO:0000313|RefSeq:XP_017314194.1,
GN ECO:0000313|RefSeq:XP_017314195.1, ECO:0000313|RefSeq:XP_017314196.1,
GN ECO:0000313|RefSeq:XP_017314197.1, ECO:0000313|RefSeq:XP_017314198.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH39054.1};
RN [1] {ECO:0000313|EMBL:AHH39054.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH39054.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017314194.1, ECO:0000313|RefSeq:XP_017314195.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017314194.1,
RC ECO:0000313|RefSeq:XP_017314195.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; JT410428; AHH39054.1; -; mRNA.
DR RefSeq; XP_017314194.1; XM_017458705.3.
DR RefSeq; XP_017314195.1; XM_017458706.3.
DR RefSeq; XP_017314196.1; XM_017458707.3.
DR RefSeq; XP_017314197.1; XM_017458708.3.
DR RefSeq; XP_017314198.1; XM_017458709.3.
DR STRING; 7998.ENSIPUP00000034857; -.
DR Ensembl; ENSIPUT00000036207; ENSIPUP00000034834; ENSIPUG00000023407.
DR Ensembl; ENSIPUT00000036220; ENSIPUP00000034849; ENSIPUG00000023407.
DR Ensembl; ENSIPUT00000036231; ENSIPUP00000034857; ENSIPUG00000023407.
DR GeneID; 108259324; -.
DR KEGG; ipu:108259324; -.
DR CTD; 327160; -.
DR OMA; MSPEHSG; -.
DR OrthoDB; 2881953at2759; -.
DR Proteomes; UP000221080; Chromosome 27.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd01208; PTB_X11; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR12345:SF12; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2; 1.
DR PANTHER; PTHR12345; SYNTENIN RELATED; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS01179; PID; 1.
PE 2: Evidence at transcript level;
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 409..596
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 609..694
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 700..776
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..105
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..225
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 790 AA; 87974 MW; 2493DCFC390EFB03 CRC64;
MAQRKRPGAS SSMASAELHA PAPCPCPTPY PSKECEERQD SETPIPPYCD QEEVDLPSSH
PVTPDHTHSN YHGHPDSLDG DSSSDYVNNT SEDEEDYDEG LPEEDEGVTY YIRYCPEDDS
YLEGMDCNEG RYGRTEPPPE TDECQEAVEE WVEGEGEVRC EVLEQDSDQQ IYDGRPEPVL
DHHPHHQYHH QDQALPQTQE QEEDDEESEE YCPNEEEEPE EEQDREVYTG DYYAPEDNGN
SMYAGHKGIE GETGEETEED IDQIVAEIKM SMSMGSLSSG TDQSPEELPP VPGRYQAEAE
PKAEPAPYPT PHRHDGRPKT LNIPPAGHNP QPQRSSKAHL HTPEERRRWA QEQHREQVSN
SAEQPRKQQR SDLNGPLENN NVPEPSKKTA SFPSFVDVPG PCEPEDLIDG IIFAANYLGS
TQLLSERNPS KNIRMMQAQE AVSRVKRVQK AAKIKKKANS EGDTQTLTEV DLFISTQRIK
VLNADTQETM MDNALRTISY IADIGNIVVL MARRRMPRSA SQDCIETTPG APEAKKQYKM
ICHVFESEDA QLIAQSIGQA FSVAYQEFLR ANGINPEDLS QKEYSDIINT QEMYNDDLIH
FSNSENCKEL LLEKQKGEIL GVVIVESGWG SILPTVILAN MMNGAPAARS GKLSIGDQIM
SINNTSLVGL PLATCQGIIK GLKNQVQVKL NIVSCPPVTT VLIKRPDLKY QLGFSVQNGI
ICSLMRGGIA ERGGVRVGHR IIEINGQSVV ATAHEKIVQA LSNSVGEIHM KTMPAAMFRL
LTGQETPMYI
//
