ID W5UCC4_ICTPU Unreviewed; 3834 AA.
AC W5UCC4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Transformation/transcription domain-associated protein {ECO:0000313|EMBL:AHH37322.1, ECO:0000313|RefSeq:XP_017339265.1};
GN Name=TRRAP {ECO:0000313|EMBL:AHH37322.1};
GN Synonyms=trrap {ECO:0000313|RefSeq:XP_017339265.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH37322.1};
RN [1] {ECO:0000313|EMBL:AHH37322.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH37322.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017339265.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017339265.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR EMBL; JT405777; AHH37322.1; -; mRNA.
DR RefSeq; XP_017339264.1; XM_017483775.1.
DR RefSeq; XP_017339265.1; XM_017483776.3.
DR STRING; 7998.ENSIPUP00000003899; -.
DR Ensembl; ENSIPUT00000004083; ENSIPUP00000003899; ENSIPUG00000002622.
DR GeneID; 108274013; -.
DR KEGG; ipu:108274013; -.
DR CTD; 8295; -.
DR OMA; CLDLYGQ; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000221080; Chromosome 13.
DR GO; GO:0060536; P:cartilage morphogenesis; IEA:Ensembl.
DR GO; GO:0035675; P:neuromast hair cell development; IEA:Ensembl.
DR GO; GO:0042481; P:regulation of odontogenesis; IEA:Ensembl.
DR GO; GO:0001964; P:startle response; IEA:Ensembl.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 2661..3232
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3475..3798
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3802..3834
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 488..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1996..2020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3241..3264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..516
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3244..3263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3834 AA; 434818 MW; 92E600CC0736AEE9 CRC64;
MAFVATPSAT VVDQTTLMKK YLQFVAALTD NNTQDETKLK MMQEVSENFE NVTSSPQYST
FLEHIIPRFL TFLQDGEVQF LQEKPTQQLR KLVLEIIHRI PTNEHLRPHV KNILSVMFRF
LEIESEENVL ICLRIIIELH KQFRPPISQE IHHFLDFVKQ IYKDLPKVVT RYFENPQVIA
ENTVPSPEMV GMITSVLVKT APEREDSETR THTIIPRGSL SLKVLAELPI IVVLMYQLYK
LNIHNVVSEF VPLIMNTIML QVTSQARQHK LYNKELYADF IAAQIKTLSF LAYIIRLYQD
LVGKYSQQMV KGMLQLLSNC PPETAHLRKE LLIAAKHILT TDLRSQFIPC MDKLFDESIL
IGSGYTARET LRPLAYSTLA DLVHHVRQNL PLTDLSLAVQ LFAKNIDDES LPSSIQTMSC
KLLLNLVDCI RSKSEQENGN GRDILMRMLE VFVLKFHTIA RYQLVSIFKK CKPQSEMGVV
DPGALPGVPA TPTATTPALP PPAPPTPVPP APPSATPFDR AGEKEDKQTF QVSDCRSLVK
TLVCGVKTIT WGITSCKAPG EAQFIPNKQL QPKETQIYIK LVKYAMQALD IYQVQIASNG
QTYIRVANCQ TVRMKEEKEV LEHFAGVFTM MNPLTFKEIF QTTVPYMVER ISKNYALQIV
ANSFLANLST SALFATILVE YLLERLPEMG SNVELSNLYL KLFKLVFGSV SLFAAENEQM
LKPHLHKIVN SSMELAQSAK EPYNYFLLLR ALFRSIGGGS HDLLYQEFLP LLPNLLQGLN
MLQSGLHKQH MKDLFVELCL TVPVRLSSLL PYLPMLMDPL VSALNGSQTL VSQGLRTLEL
CVDNLQPDFL YDHIQPVRAE LMQALWRTLR NPAETISHVA YRVLGKFGGS NRKMLKESQR
LQYVVTEVQG PSIKAEFTDC KASVQLPMEK AIETALDCLK SANTEPYYRR QAWEVIKCFL
VAMTSLEDNK HALYQLLAHP NFTEKWIPNV IISHRYKAQD TPARRTFEQA LTGAFMSAVI
KDLRPSALPF VASLIRHYTM VAVAQQCGPF LLPCYQLGSQ PSTAMFHSEE NGSKGMDPLV
LIDAIAICMA YEEKELCKIG EVALAVIFDV ASIILGSKER ACQLPLFSYI VERLCACCYE
QAWYAKLGGV VSIKFLMERL PLIWVLQNQL TFLKALLFVM MDLTGEVSNG AVAMAKTTLE
QLLVRCATPL KEEEKTEELL SAQDKSFHMV THDLVREVTS PNSTVRKQAM HSLQVLAQVT
GKSVTIIMEP HKEVLQDMVP PKKHLLRHQP ANAQIGLMEG NTFCTTLQPR LFTMDLGVVE
HKVFYTELLN LCEAEDAALM KLPCYKSLPS LVPLRIAALN ALAACNYLPQ SREKIIAALF
KALNSTNSEL QEAGEACMRK FLEGATIEVD QIHTHMRPLL MMLGDYRSLT LNVVNRLTSV
TRLFPNSFND KFCDQMMQHL RKWMEVVVLT HKGGQRSDGS EMKICSAIIN LFHLIPAAPQ
TLVKPLLEVV MKTERAMLIE AGSPFREPLI KFLTRHPSQT VELFMMEATL NDPQWSRMFM
SFLKHKDAKP LRDVLASNPS RFVPLLVPAG TPGTVRPGSP STSTARLDLQ FQAIKIISII
VKNDEGWLAS QHSLVSQLRR VWVSEAFQER HRKDNMAATN WKEPKLLAYC LLSYCKRNYS
EIELLFQLLR AFTGRFLCNM TFLKEYMEEE IPKNYSIAHK RALFFRFVEF NDPQFNDELK
AKVLQHILHP AFLYSFEKGE GEQLLGPPNP EGDNPESITS VFITKVLDPE KQSDLLDSLR
INLLQFSTLL VEHAPHHIHD NNKSRNSKLR RLMTFAWPCL LPKACVDPAC KYSGHLLLAH
IIAKFAIHKK IVLQVFHSLL KAHTMEARAI VRQAMAILTP AVPARMEDGH QMLTHWTRKI
IVEEGHTVPQ LVHILHLIVQ HFRVYYPVRH HLVQHMISAM QRLGFTPSVT IEQRKLAVDL
AEVVIKWELQ RIKDQQPESE ADAAAGGEGT SSGALKRGAS VDSAQDVKRF RTATGAVGTV
FGRSQSMPGT EALLTKPVEK QHTDTVVNFL IRIACQVNDV SSVAGSPGEL LSRRCVNLMK
MALRPDMWPR AELKLQWFDK LLMTVEQPAQ ANFSNICTGL EILSFLLTVL QSPAILTHFK
PLQRGIAACM TCGNTKVLRA VHSLLSRLMS IFPTEPSTSS VASKYEELEC LYAAVGKVIY
EGLTNYEKAT SANPTQLFGT LMILKSACSY NSSYIDRLIS VFMRSLQKMV REHLSPQTNP
GATETSAVTS ELVMLSLDLV KTRLSVMNME MRKNFIQVIL TSLIEKSPDP KVLRAVVKIV
EEWVKNNSPM ASNQMPNLRE KSILLVKMMT YIEKRFPDDL ELNAQFLDLV NYVYRDESLS
GSDITSKLEP AFLSGLRCAQ PLIRAKFFEV FDASMKRRVY ERLLYICCSQ NWEAMGSHFW
IKQCIELLLA VCEKGSIIGT SCQGSMLPSI TNVINLADSH DRAAFAMATH IKQEPREREN
SETKEEDVEI DIELAPGDQT SLPKTKEQAE RDAGNQLHML TNRHDKFLDS LREVKTGALL
NALIQLCHIS TPLAEKTWVQ LFPRLWKILS DRQQHALSGE MGPFLCSGSH QAQRDCQPSA
LNCFVEAMSQ CVPPIPIRPC VLKYLGKTHN LWLRSTLMLE QQAFEKGLSL HIKPKQSTEF
YEQESITPPQ QEILDSLAEL YSLLQEEDMW AGLWQKRCKF PETSTAIAYE QHGFFEQAQE
SYEKAMEKAR KEHERTNTSP AIFPEYQLWE DHWIRCSKEL NQWEALTEYG QSKGHTNAYL
VLECAWRVSN WAAMKEALVQ VELSCPKEMA WKVNMHRGYL AICHPEEQQL NFIERLVEMA
SSLAIREWRR LPHIVSHVHT PLLQAAQQII ELQEAAQINV GLQPANLGRN TSLHDMKTVV
KTWRNRLPIV SDDLSHWSSI FMWRQHHYQA IVSAYESNTQ HDPNTNNAML GVHASASAII
QYGKIARKQG LVNVALDILS RIHTIPTVPI VDCFQKIRQQ VKCYLQLAGV MGKNECMQGL
EVIESTNLKY FTKEMTAEFY ALKGMFLAQI NKSEEANKAF SAAVQMHDVL VKAWAMWGDY
LENIFVKDRQ SHLGVSAITC YLHACRHQNE SKSRKYLAKV LWLLSFDDKN TLADAVDKYC
IGVPPIQWLA WIPQLLTCLV GSEGKPLLNL ISQVGRVYPQ AVYFPIRTLY LTLKIEQRER
YKSDSGQQQP SSMGAQSHSA SDPGPIRATA PMWRCSRIMH MQRELHPTLL SSLEGIVDQM
VWFRENWHEE VLRQLQQGLA KCHSVAFEKS GAVSDAKITP HTLNFVKKLV STFGVGLENV
SNVSTMFSSA ASESLARRAQ ATAQDPVFQK MKGQFTTDFD FSVPGSMKLH NLISKLKKWI
KILEAKTKQL PKFFLIEEKC RFLSNFSAQT AEVEIPGEFL MPKPTHYYIK IARFMPRVEI
VQKHNTAARR LYIRGHNGKI YPYLVMNDAC LTESRREERV LQLLRLLNPC LEKRKETTKR
HLFFTVPRVV AVSPQMRLVE DNPSSLSLVE IYKQRCAKKG IEHDNPISRY YDRLATVQAR
GTQASHQVLR DILKEVQGNM VPRSMLKEWA LHTFPNATDY WTFRKMFTIQ LALIGLAEFM
LHLNRLNPEM LQIAQDTGKL NVSYFRFDIN DATGDLDANR PVPFRLTPNI SEFLTTIGVS
GPLTASMIAV ARCFAQPNFK VDGILKAVLR DEIIAWHKKT QEDTSMPLSP AGQPENMDSQ
QLVSLVQKAV SAIMTRLHSL AQFEGGESKV NTLVAAANSL DNLCRMDPAW HPWL
//
