ID   W5UDF3_ICTPU            Unreviewed;       631 AA.
AC   W5UDF3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Leucine-rich repeat-containing protein 4C {ECO:0000313|EMBL:AHH39988.1, ECO:0000313|RefSeq:XP_017314213.1};
GN   Name=Lrrc4c {ECO:0000313|EMBL:AHH39988.1};
GN   Synonyms=lrrc4cb {ECO:0000313|RefSeq:XP_017314213.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH39988.1};
RN   [1] {ECO:0000313|EMBL:AHH39988.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Mixed {ECO:0000313|EMBL:AHH39988.1};
RX   PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA   Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA   Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA   Peatman E., Liu Z.;
RT   "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT   Seq analysis of a doubled haploid homozygote.";
RL   BMC Genomics 13:595-595(2012).
RN   [2] {ECO:0000313|RefSeq:XP_017314213.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017314213.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Synaptic cell membrane {ECO:0000256|ARBA:ARBA00034109}.
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DR   EMBL; JT412772; AHH39988.1; -; mRNA.
DR   RefSeq; XP_017314213.1; XM_017458724.3.
DR   STRING; 7998.ENSIPUP00000033613; -.
DR   Ensembl; ENSIPUT00000034935; ENSIPUP00000033613; ENSIPUG00000022604.
DR   GeneID; 108259330; -.
DR   KEGG; ipu:108259330; -.
DR   CTD; 564462; -.
DR   OMA; NNGVTYF; -.
DR   OrthoDB; 4239630at2759; -.
DR   Proteomes; UP000221080; Chromosome 27.
DR   GO; GO:0097060; C:synaptic membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR24369:SF8; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 4C; 1.
DR   Pfam; PF13927; Ig_3; 1.
DR   Pfam; PF13306; LRR_5; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00365; LRR_SD22; 3.
DR   SMART; SM00369; LRR_TYP; 9.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..45
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           46..631
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013540175"
FT   TRANSMEM        522..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          355..444
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   631 AA;  71020 MW;  67306E0CC27B1058 CRC64;
     MLNKMTSYHQ HQMMRGPRWK GAWFDPLFLL LLALQLLAVA GLVRAQTCPS VCSCSNQFSK
     VICTRRGLRE VPDGISTNTR YLNLQDNLIQ VIKVDSFKHL RHLEILQLSK NHIRNIEIGA
     FNGLTSLNTL ELFDNRLTTI PNGAFEYLSK LKELWLRNNP IESIPSYAFN RLPSLRRLDL
     GELKRLSYIS DGAFEGLSNL RYLNMGMCNL KEVPNIRPLV RLDELEMSGN QLTVIQPGSF
     KGLIHLQKLW MMHSQIQTIE RNSFDDLQSL SELNLAHNNL TFVPHDLFTP LRHLQRVHLH
     HNPWNCNCDI LWLSWWLRET VPTNTSCCAR CNSPASLKGR YIGELDQSYF QCYAPVIVEP
     PADLNVTEGI AVELKCRTNS LTSVSWLTPG GSIMTHGASQ ARVMVQNDGT LNFTRVTMHD
     TGNYTCMVSN MLGNISASAV LNVTSIDNSG FSYFTTVTVE TIEPPTDGLS RTPEQSSFGW
     VASSTTRATP ISTEKAYTIP VTDVDNEGAL NGLEEVMKTT KIIIGCFVAI TLMAAVMLII
     FYKMRKQHHQ QDHNGPTRTM EIISVDDELA GVPAMESHLP LPPLEHDHYN HYNSYKSAYN
     HASTLGSLHS SVHEPLLIQA SSKDNVQETQ I
//