ID   W5UDP2_ICTPU            Unreviewed;       267 AA.
AC   W5UDP2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Aquaporin-8 {ECO:0000313|EMBL:AHH40083.1, ECO:0000313|RefSeq:XP_017341894.1};
GN   Name=AQP8 {ECO:0000313|EMBL:AHH40083.1};
GN   Synonyms=LOC108275528 {ECO:0000313|RefSeq:XP_017341894.1};
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH40083.1};
RN   [1] {ECO:0000313|EMBL:AHH40083.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Mixed {ECO:0000313|EMBL:AHH40083.1};
RX   PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA   Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA   Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA   Peatman E., Liu Z.;
RT   "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT   Seq analysis of a doubled haploid homozygote.";
RL   BMC Genomics 13:595-595(2012).
RN   [2] {ECO:0000313|RefSeq:XP_017341894.1}
RP   IDENTIFICATION.
RC   TISSUE=Blood {ECO:0000313|RefSeq:XP_017341894.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000256|ARBA:ARBA00006175, ECO:0000256|RuleBase:RU000477}.
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DR   EMBL; JT413011; AHH40083.1; -; mRNA.
DR   RefSeq; XP_017341894.1; XM_017486405.3.
DR   STRING; 7998.ENSIPUP00000008127; -.
DR   Ensembl; ENSIPUT00000008486; ENSIPUP00000008127; ENSIPUG00000005591.
DR   GeneID; 108275528; -.
DR   KEGG; ipu:108275528; -.
DR   OMA; MHYEEAN; -.
DR   OrthoDB; 3236018at2759; -.
DR   Proteomes; UP000221080; Chromosome 2.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   GO; GO:0015204; F:urea transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0005372; F:water transmembrane transporter activity; IEA:Ensembl.
DR   Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR023277; Aquaporin_8.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   InterPro; IPR022357; MIP_CS.
DR   PANTHER; PTHR45665:SF6; AQP8A PROTEIN; 1.
DR   PANTHER; PTHR45665; AQUAPORIN-8; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR02020; AQUAPORIN8.
DR   PRINTS; PR00783; MINTRINSICP.
DR   SUPFAM; SSF81338; Aquaporin-like; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000477};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000477}.
FT   TRANSMEM        42..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        77..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        107..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        192..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        236..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   267 AA;  28262 MW;  CC38FA2425498A97 CRC64;
     MSTHQSKTNS DTDMCNSVSV FDIEPEEDET VIHRLVSVFQ PYIQPCIAEL VGSTLFIFTG
     CMSVIENPQD TGSLQPALAH GLALSIVIAL FGEISGGHFN PAVSVSVYLI GGLNVILLIP
     YILAQLCGGL IGAGLAKSIS LPHNYYNASG GAFNTVQERA QIEPAVIAEI VMTLFLTMSV
     CMGAVNGKTR TLLAPFCIGL TVAADVLAGG AVSGACMNPA RAFGPAAVAN YWTYHWIYWV
     GPMAGALLTA TLIRLMLGDK KIRVILK
//