ID W5UEE8_ICTPU Unreviewed; 298 AA.
AC W5UEE8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Claudin-8 {ECO:0000313|EMBL:AHH39959.1, ECO:0000313|RefSeq:XP_017346420.1};
GN Name=CLDN8 {ECO:0000313|EMBL:AHH39959.1};
GN Synonyms=cldn8.1 {ECO:0000313|RefSeq:XP_017346420.1};
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998 {ECO:0000313|EMBL:AHH39959.1};
RN [1] {ECO:0000313|EMBL:AHH39959.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Mixed {ECO:0000313|EMBL:AHH39959.1};
RX PubMed=23127152; DOI=10.1186/1471-2164-13-595;
RA Liu S., Zhang Y., Zhou Z., Waldbieser G., Sun F., Lu J., Zhang J.,
RA Jiang Y., Zhang H., Wang X., Rajendran K.V., Khoo L., Kucuktas H.,
RA Peatman E., Liu Z.;
RT "Efficient assembly and annotation of the transcriptome of catfish by RNA-
RT Seq analysis of a doubled haploid homozygote.";
RL BMC Genomics 13:595-595(2012).
RN [2] {ECO:0000313|RefSeq:XP_017346420.1}
RP IDENTIFICATION.
RC TISSUE=Blood {ECO:0000313|RefSeq:XP_017346420.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the claudin family.
CC {ECO:0000256|ARBA:ARBA00008295}.
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DR EMBL; JT412699; AHH39959.1; -; mRNA.
DR RefSeq; XP_017346420.1; XM_017490931.3.
DR STRING; 7998.ENSIPUP00000003738; -.
DR Ensembl; ENSIPUT00000003916; ENSIPUP00000003738; ENSIPUG00000002646.
DR GeneID; 108277893; -.
DR KEGG; ipu:108277893; -.
DR CTD; 445278; -.
DR OMA; FRCIFIC; -.
DR OrthoDB; 4040914at2759; -.
DR Proteomes; UP000221080; Chromosome 17.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; CLAUDIN; 1.
DR PANTHER; PTHR12002:SF24; CLAUDIN-8; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01077; CLAUDIN.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 2: Evidence at transcript level;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..298
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013540248"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 298 AA; 33015 MW; 06E3F68F6A293BE8 CRC64;
MAGQPMELAA LILSLLGLIG VSASTGMPMW RVTAFIGENI IVMETRYEGL WMNCYRQANI
RMQCKVYDSL LALTPDLQAA RGLMCCSVAL AAIGLFIAIT GMKCTACIQG NERAKRMVLI
VAGSLIILAC ICSLIPVSWT GNVIIRDFYN PLLIDAQRRE LGEALYIGWV SSALLFVGGC
IFACCGGSGK EKRADQTPRY DYKRDMSYVA YQPQPQQMAY QPRPAAAYSF ASREPSFIQT
STQPSIVQTS RQQSFIQPSR QQSFIQPSRQ QSFIQPSRQQ SFIQPSRQLS VRSGVAYL
//
